Lyophilized hybrid nanostructured lipid carriers to enhance the cellular uptake of verapamil: statistical optimization and in vitro evaluation

• Main Authors: Khan, Arshad Ali, Abdulbaqi, Ibrahim M., Assi, Reem Abou, Vikneswaran, Murugaiyah, Yusrida, Darwis
• Format: Article
• Language: English
• Published: Springer Open 2018
• Subjects: TP Chemical technology
• Online Access: http://umpir.ump.edu.my/id/eprint/29850/1/Lyophilized%20hybrid%20nanostructured%20lipid%20carriers%20to%20enhance%20the%20cellular.pdf; http://umpir.ump.edu.my/id/eprint/29850/; https://doi.org/10.1186/s11671-018-2744-6; https://doi.org/10.1186/s11671-018-2744-6

Verapamil is a calcium channel blocker and highly effective in the treatment of hypertension, angina pectoris, and other diseases. However, the drug has a low bioavailability of 20 to 35% due to the first pass effect. The main objective of this study was to develop hybrid verapamil-dextran nanostruc...