Ramification of Zinc oxide and Hydroxyapatite doped Biocomposites for the Interaction of Osteoblasts for Mineralization

Far-flung evolution in tissue engineering enabled the development of bioactive and biodegradable materials to generate biocomposite nanofibrous scaffolds for bone repair and replacement therapies. Polymeric bioactive nanofibers are to biomimic the native extracellular matrix (ECM), delivering tremen...

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Main Authors: Gnaneshwar, Puvala Vijayakumar, Shruthi, Vathaluru Sudakaran, Abisegapriyana, Sivasubramanian, Jositta, Sherine, Seeram, Ramakrishna, Mohd Hasbi, Ab. Rahim, Rajan, Jose, Venugopal, Jayarama Reddy
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Language:English
Published: Elsevier 2018
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Online Access:http://umpir.ump.edu.my/id/eprint/29673/1/Materials%20Science%20and%20Engineering%20C%2096%202019%20337-346.pdf
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spelling my.ump.umpir.296732020-10-23T04:18:57Z http://umpir.ump.edu.my/id/eprint/29673/ Ramification of Zinc oxide and Hydroxyapatite doped Biocomposites for the Interaction of Osteoblasts for Mineralization Gnaneshwar, Puvala Vijayakumar Shruthi, Vathaluru Sudakaran Abisegapriyana, Sivasubramanian Jositta, Sherine Seeram, Ramakrishna Mohd Hasbi, Ab. Rahim Rajan, Jose Venugopal, Jayarama Reddy RZ Other systems of medicine Far-flung evolution in tissue engineering enabled the development of bioactive and biodegradable materials to generate biocomposite nanofibrous scaffolds for bone repair and replacement therapies. Polymeric bioactive nanofibers are to biomimic the native extracellular matrix (ECM), delivering tremendous regenerative potentials for drug delivery and tissue engineering applications. It's been known from few decades that Zinc oxide (ZnO) nanoparticles are enhancing bone growth and providing proliferation of osteoblasts when incorporated with hydroxyapatite (HAp). We attempted to investigate the interaction between the human foetal osteoblasts (hFOB) with ZnO doped HAp incorporated biocomposite poly(L-lactic acid)-co-poly(ε-caprolactone) and silk fibroin (PLACL/SF) nanofibrous scaffolds for osteoblasts mineralization in bone tissue regeneration. The present study, we doped ZnO with HAp (ZnO(HAp) using the sol-gel ethanol condensation technique. The properties of PLACL/SF/ZnO(HAp) biocomposite nanofibrous scaffolds enhanced with doped and blended ZnO/HAp were characterized using Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), Contact angle and Tensile studies to determine the morphology, functionality, wettability and stability. The in vitro study results showed that the addition of ZnO and HAp enhances the secretion of bone mineral matrix (98%) with smaller fiber diameter (139.4 ± 27 nm) due to the presence of silk fibroin showing potential tensile properties (322.4%), and increased the proliferation of osteoblasts for bone tissue regeneration. Elsevier 2018-11-24 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/29673/1/Materials%20Science%20and%20Engineering%20C%2096%202019%20337-346.pdf Gnaneshwar, Puvala Vijayakumar and Shruthi, Vathaluru Sudakaran and Abisegapriyana, Sivasubramanian and Jositta, Sherine and Seeram, Ramakrishna and Mohd Hasbi, Ab. Rahim and Rajan, Jose and Venugopal, Jayarama Reddy (2018) Ramification of Zinc oxide and Hydroxyapatite doped Biocomposites for the Interaction of Osteoblasts for Mineralization. Materials Science & Engineering C, 96. pp. 337-346. ISSN 0928-4931 http://www.elsevier.com/locate/msec nonhttps:// doi.org/10.1016/j.msec.2018.11.033
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic RZ Other systems of medicine
spellingShingle RZ Other systems of medicine
Gnaneshwar, Puvala Vijayakumar
Shruthi, Vathaluru Sudakaran
Abisegapriyana, Sivasubramanian
Jositta, Sherine
Seeram, Ramakrishna
Mohd Hasbi, Ab. Rahim
Rajan, Jose
Venugopal, Jayarama Reddy
Ramification of Zinc oxide and Hydroxyapatite doped Biocomposites for the Interaction of Osteoblasts for Mineralization
description Far-flung evolution in tissue engineering enabled the development of bioactive and biodegradable materials to generate biocomposite nanofibrous scaffolds for bone repair and replacement therapies. Polymeric bioactive nanofibers are to biomimic the native extracellular matrix (ECM), delivering tremendous regenerative potentials for drug delivery and tissue engineering applications. It's been known from few decades that Zinc oxide (ZnO) nanoparticles are enhancing bone growth and providing proliferation of osteoblasts when incorporated with hydroxyapatite (HAp). We attempted to investigate the interaction between the human foetal osteoblasts (hFOB) with ZnO doped HAp incorporated biocomposite poly(L-lactic acid)-co-poly(ε-caprolactone) and silk fibroin (PLACL/SF) nanofibrous scaffolds for osteoblasts mineralization in bone tissue regeneration. The present study, we doped ZnO with HAp (ZnO(HAp) using the sol-gel ethanol condensation technique. The properties of PLACL/SF/ZnO(HAp) biocomposite nanofibrous scaffolds enhanced with doped and blended ZnO/HAp were characterized using Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), Contact angle and Tensile studies to determine the morphology, functionality, wettability and stability. The in vitro study results showed that the addition of ZnO and HAp enhances the secretion of bone mineral matrix (98%) with smaller fiber diameter (139.4 ± 27 nm) due to the presence of silk fibroin showing potential tensile properties (322.4%), and increased the proliferation of osteoblasts for bone tissue regeneration.
format Article
author Gnaneshwar, Puvala Vijayakumar
Shruthi, Vathaluru Sudakaran
Abisegapriyana, Sivasubramanian
Jositta, Sherine
Seeram, Ramakrishna
Mohd Hasbi, Ab. Rahim
Rajan, Jose
Venugopal, Jayarama Reddy
author_facet Gnaneshwar, Puvala Vijayakumar
Shruthi, Vathaluru Sudakaran
Abisegapriyana, Sivasubramanian
Jositta, Sherine
Seeram, Ramakrishna
Mohd Hasbi, Ab. Rahim
Rajan, Jose
Venugopal, Jayarama Reddy
author_sort Gnaneshwar, Puvala Vijayakumar
title Ramification of Zinc oxide and Hydroxyapatite doped Biocomposites for the Interaction of Osteoblasts for Mineralization
title_short Ramification of Zinc oxide and Hydroxyapatite doped Biocomposites for the Interaction of Osteoblasts for Mineralization
title_full Ramification of Zinc oxide and Hydroxyapatite doped Biocomposites for the Interaction of Osteoblasts for Mineralization
title_fullStr Ramification of Zinc oxide and Hydroxyapatite doped Biocomposites for the Interaction of Osteoblasts for Mineralization
title_full_unstemmed Ramification of Zinc oxide and Hydroxyapatite doped Biocomposites for the Interaction of Osteoblasts for Mineralization
title_sort ramification of zinc oxide and hydroxyapatite doped biocomposites for the interaction of osteoblasts for mineralization
publisher Elsevier
publishDate 2018
url http://umpir.ump.edu.my/id/eprint/29673/1/Materials%20Science%20and%20Engineering%20C%2096%202019%20337-346.pdf
http://umpir.ump.edu.my/id/eprint/29673/
http://www.elsevier.com/locate/msec
_version_ 1681489643100438528
score 13.187195