A hybrid of particle swarm optimization and minimization of metabolic adjustment for ethanol production of escherichia coli

Ethanol is a chemical-colourless compound that widely used in pharmaceutical, medicines, food products, and industrial applications. As the demand for ethanol is rising recently, attention has been given on metabolic engineering of Escherichia coli (E.coli) to enhance its production through alterati...

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Main Authors: Lee, Mee K., Mohd Saberi, Mohamad, Choon, Yee Wen, Kauthar, Mohd Daud, Nurul Athirah, Nasarudin, Mohd Arfian, Ismail, Zuwairie, Ibrahim, Suhaimi, Napis, Sinnott, Richard O.
Format: Conference or Workshop Item
Language:English
Published: Springer Verlag 2020
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Online Access:http://umpir.ump.edu.my/id/eprint/25633/1/A%20hybrid%20of%20particle%20swarm%20optimization%20and%20minimization%20.pdf
http://umpir.ump.edu.my/id/eprint/25633/
https://doi.org/10.1007/978-3-030-23873-5_5
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Summary:Ethanol is a chemical-colourless compound that widely used in pharmaceutical, medicines, food products, and industrial applications. As the demand for ethanol is rising recently, attention has been given on metabolic engineering of Escherichia coli (E.coli) to enhance its production through alteration of its genetic content. This research mainly aimed to optimize ethanol production in E.coli using a gene knockout strategy. Several gene knockout strategies like OptKnock and OptGene have been proposed previously. However, most of them suffer from premature convergence. Hence, a hybrid of Particle Swarm Optimization (PSO) and Minimization of Metabolic Adjustment (MOMA) algorithm is proposed to identify the list of gene knockouts in maximizing the ethanol production and growth rate of E.coli. Experiment results show that the hybrid method is comparable with two state-of-the-art methods in term of growth rate and production.