Synthetic Curcumin Derivative DK1 Possessed G2M Arrest and Induced Apoptosis Through Accumulation of Intracellular ROS in MCF-7 Breast Cancer Cells

• Main Authors: Norlaily, Mohd Ali, Swee, Keong Yeap, Nadiah, Abu, Kian, Lam Lim, Huynh, Ky, Ahmad Zaim, Mat Pauz, Wan, Yong Ho, Sheau, Wei Tan, Han, Kiat Alan‑Ong, Seema, Zareen, Noorjahan Banu, Alitheen, Akhtar, Muhammad Nadeem
• Format: Article
• Language: English
• Published: BioMed Central 2017
• Subjects: Q Science (General)
• Online Access: http://umpir.ump.edu.my/id/eprint/17149/1/Synthetic%20curcumin%20derivative%20DK1%20possessed%20G2M%20arrest%20and%20induced%20apoptosis%20through%20accumulation%20of%20intracellular%20ROS%20in%20MCF-7%20breast%20cancer%20cells.pdf; http://umpir.ump.edu.my/id/eprint/17149/; https://doi.org/10.1186/s12935-017-0400-3

Aims: Curcumin is a lead compound of the rhizomes of Curcuma longa and possess a broad range of pharmaco logical activities. Chemically, curcumin is 1,3-dicarbonyl class of compound, which exhibits keto-enol tautomerism. Despite of its strong biological properties, curcumin has yet been recommended...