Synthesis and Cytotoxic Effects of (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one in MDA-MB231 and MCF-7 Breast Cancer Cell Lines

• Main Authors: Akhtar, Muhammad Nadeem, Ali Salim, Landa Zeenelabdin, Swee, Keong Yeap, Nadiah, Abu, Seema, Zareen, Kong, Mun Lo, Addila, Abu Bakar, Noorjahan Banu, Alitheen
• Format: Article
• Language: English
• Published: Elsevier Ltd 2017
• Subjects: Q Science (General)
• Online Access: http://umpir.ump.edu.my/id/eprint/16454/1/fist-2017-nadeem-Synthesis%20and%20cytotoxic1.pdf; http://umpir.ump.edu.my/id/eprint/16454/; https://doi.org/10.1016/j.phytol.2016.12.022

A chalcone derivative, (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)-prop-2-en-1-one (DMMF) was synthesized and evaluated against various cancerous cell lines including colon adenocarcinoma (HT-29), myloplasticleukemia (HL60), breast cancer (MCF-7 and MDA-MB231), normal hepatic cell (WRL-68) an...