A Newton Cooperative Genetic Algorithm Method for In Silico Optimization of Metabolic Pathway Production

• Main Authors: Mohd Arfian, Ismail, Safaai, Deris, Mohd Saberi, Mohamad, Afnizanfaizal, Abdullah
• Format: Article
• Language: English
• Published: Public Library of Science 2015
• Subjects: QA75 Electronic computers. Computer science; QD Chemistry
• Online Access: http://umpir.ump.edu.my/id/eprint/11777/1/A%20Newton%20Cooperative%20Genetic%20Algorithm%20Method%20for%20In%20Silico%20Optimization%20of%20Metabolic%20Pathway%20Production.pdf; http://umpir.ump.edu.my/id/eprint/11777/; http://dx.doi.org/10.1371/journal.pone.0126199

This paper presents an in silico optimization method of metabolic pathway production. The metabolic pathway can be represented by a mathematical model known as the generalized mass action model, which leads to a complex nonlinear equations system. The optimization process becomes difficult when stea...