Cytotoxicity and toxicity evaluation of Xanthone Crude Extract on Hypoxic Human Hepatocellular Carcinoma and Zebrafish (Danio rerio) embryos

• Main Authors: Shazrul Fazry, Muhammad Akram Mohd Noordin, Salahuddin Sanusi, Mahanem Mat Noor, Wan Mohd Aizat, Azwan Mat Lazim, Herryawan Ryadi Eziwar Dyari, Nur Hidayah Jamar, Juwairiah Remali, Babul Airianah Othman, Douglas Law, Nik Marzuki Sidik, Yew Hoong Cheah, Yi Chieh Lim
• Format: Indexed Article
• Language: English
• Published: MDPI 2018
• Online Access: http://discol.umk.edu.my/id/eprint/7400/1/toxics-06-00060.pdf; http://discol.umk.edu.my/id/eprint/7400/; https://doi.org/10.3390/toxics6040060

Xanthone is an organic compound mostly found in mangosteen pericarp and widely known for its anti-proliferating effect on cancer cells. In this study, we evaluated the effects of xanthone crude extract (XCE) and α-mangostin (α-MG) on normoxic and hypoxic human hepatocellular carcinoma (HepG2) cells...