Virtual screening and biological assay of compound libraries for anticholinesterase activity / Sri Devi D/O Sukumaran

• Main Author: Sukumaran, Sri Devi
• Format: Thesis
• Published: 2012
• Subjects: R Medicine (General)
• Online Access: http://studentsrepo.um.edu.my/5657/5/TITLE_PAGE_(NEW).pdf; http://studentsrepo.um.edu.my/5657/2/FRONT_PAGE_(NEW).pdf; http://studentsrepo.um.edu.my/5657/3/PREFACE.pdf; http://studentsrepo.um.edu.my/5657/4/THESIS.pdf; http://studentsrepo.um.edu.my/5657/1/APPENDIX.pdf; http://studentsrepo.um.edu.my/5657/

The current research was aimed at finding peripheral anionic site (PAS) binding acetylcholinesterase (AChE) inhibitors to be used in the treatment of Alzheimer’s disease (AD). The crystal structure of human acetylcholinesterase (hAChE) in complex with fasciculin II (2.76 Ǻ) (PDB ID: 1b41) was found...