High In-Vitro Antitumour Activity of Triphenyltin Coumarin 3-Carboxylate and its Coordination Complexes With Monodentate Oxygen Donor Ligands Against the Epstein Barr Virus (EBV)-DNA Positive Raji and the P-388 Murine Leukaemia Cell Lines, and Evidence for the Suppression by Organotin of the Early Antigen Complex in the EBV Lytic Cycle.

• Main Authors: Koshy, Joyce, Das, V.G., Balabaskaran, S., Ng, S.W., Wahab, Norhanom
• Format: Article
• Published: Hindawi Publishing Corporation 2000
• Subjects: QD Chemistry; QH Natural history
• Online Access: http://eprints.um.edu.my/998/; http://dx.doi.org/10.1155/MBD.2000.245

Triphenyltin coumarin-3-carboxylate and its coordination complexes with ethanol, triphenylphosphine oxide, triphenylarsine oxide, diphenylcyclopropenone and quinoline N-oxide exhibited high in vitro cytotoxicity (LC(50) values in the range 0.25-3.4 mug/mL) when tested against EBV-DNA positive Raji c...