Vacuum/Compression Valving (VCV) using parrafin-wax on a centrifugal microfluidic CD platform
This paper introduces novel vacuum/compression valves (VCVs) utilizing paraffin wax. A VCV is implemented by sealing the venting channel/hole with wax plugs (for normally-closed valve), or to be sealed by wax (for normally-open valve), and is activated by localized heating on the CD surface. We demo...
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Public Library of Science
2013
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Online Access: | http://eprints.um.edu.my/9355/1/VacuumCompression_Valving_%28VCV%29_Using_Parrafin-Wax_on_a_Centrifugal_Microfluidic_CD_Platform.pdf http://eprints.um.edu.my/9355/ https://doi.org/10.1371/journal.pone.0058523 |
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my.um.eprints.93552019-11-20T04:35:36Z http://eprints.um.edu.my/9355/ Vacuum/Compression Valving (VCV) using parrafin-wax on a centrifugal microfluidic CD platform Al-Faqheri, Wisam Ibrahim, Fatimah Thio, Tzer Hwai Gilbert Moebius, Jacob Joseph, Karunan Arof, Hamzah Madou, Marc T Technology (General) TA Engineering (General). Civil engineering (General) TJ Mechanical engineering and machinery TK Electrical engineering. Electronics Nuclear engineering This paper introduces novel vacuum/compression valves (VCVs) utilizing paraffin wax. A VCV is implemented by sealing the venting channel/hole with wax plugs (for normally-closed valve), or to be sealed by wax (for normally-open valve), and is activated by localized heating on the CD surface. We demonstrate that the VCV provides the advantages of avoiding unnecessary heating of the sample/reagents in the diagnostic process, allowing for vacuum sealing of the CD, and clear separation of the paraffin wax from the sample/reagents in the microfluidic process. As a proof of concept, the microfluidic processes of liquid flow switching and liquid metering is demonstrated with the VCV. Results show that the VCV lowers the required spinning frequency to perform the microfluidic processes with high accuracy and ease of control. Public Library of Science 2013 Article PeerReviewed application/pdf en http://eprints.um.edu.my/9355/1/VacuumCompression_Valving_%28VCV%29_Using_Parrafin-Wax_on_a_Centrifugal_Microfluidic_CD_Platform.pdf Al-Faqheri, Wisam and Ibrahim, Fatimah and Thio, Tzer Hwai Gilbert and Moebius, Jacob and Joseph, Karunan and Arof, Hamzah and Madou, Marc (2013) Vacuum/Compression Valving (VCV) using parrafin-wax on a centrifugal microfluidic CD platform. PLoS ONE, 8 (3). e58523. ISSN 1932-6203 https://doi.org/10.1371/journal.pone.0058523 doi:10.1371/journal.pone.0058523 |
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T Technology (General) TA Engineering (General). Civil engineering (General) TJ Mechanical engineering and machinery TK Electrical engineering. Electronics Nuclear engineering |
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T Technology (General) TA Engineering (General). Civil engineering (General) TJ Mechanical engineering and machinery TK Electrical engineering. Electronics Nuclear engineering Al-Faqheri, Wisam Ibrahim, Fatimah Thio, Tzer Hwai Gilbert Moebius, Jacob Joseph, Karunan Arof, Hamzah Madou, Marc Vacuum/Compression Valving (VCV) using parrafin-wax on a centrifugal microfluidic CD platform |
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This paper introduces novel vacuum/compression valves (VCVs) utilizing paraffin wax. A VCV is implemented by sealing the venting channel/hole with wax plugs (for normally-closed valve), or to be sealed by wax (for normally-open valve), and is activated by localized heating on the CD surface. We demonstrate that the VCV provides the advantages of avoiding unnecessary heating of the sample/reagents in the diagnostic process, allowing for vacuum sealing of the CD, and clear separation of the paraffin wax from the sample/reagents in the microfluidic process. As a proof of concept, the microfluidic processes of liquid flow switching and liquid metering is demonstrated with the VCV. Results show that the VCV lowers the required spinning frequency to perform the microfluidic processes with high accuracy and ease of control. |
format |
Article |
author |
Al-Faqheri, Wisam Ibrahim, Fatimah Thio, Tzer Hwai Gilbert Moebius, Jacob Joseph, Karunan Arof, Hamzah Madou, Marc |
author_facet |
Al-Faqheri, Wisam Ibrahim, Fatimah Thio, Tzer Hwai Gilbert Moebius, Jacob Joseph, Karunan Arof, Hamzah Madou, Marc |
author_sort |
Al-Faqheri, Wisam |
title |
Vacuum/Compression Valving (VCV) using parrafin-wax on a centrifugal microfluidic CD platform |
title_short |
Vacuum/Compression Valving (VCV) using parrafin-wax on a centrifugal microfluidic CD platform |
title_full |
Vacuum/Compression Valving (VCV) using parrafin-wax on a centrifugal microfluidic CD platform |
title_fullStr |
Vacuum/Compression Valving (VCV) using parrafin-wax on a centrifugal microfluidic CD platform |
title_full_unstemmed |
Vacuum/Compression Valving (VCV) using parrafin-wax on a centrifugal microfluidic CD platform |
title_sort |
vacuum/compression valving (vcv) using parrafin-wax on a centrifugal microfluidic cd platform |
publisher |
Public Library of Science |
publishDate |
2013 |
url |
http://eprints.um.edu.my/9355/1/VacuumCompression_Valving_%28VCV%29_Using_Parrafin-Wax_on_a_Centrifugal_Microfluidic_CD_Platform.pdf http://eprints.um.edu.my/9355/ https://doi.org/10.1371/journal.pone.0058523 |
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1651867353747554304 |
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13.188404 |