Common oncogenic mutations are infrequent in oral squamous cell carcinoma of asian origin

• Main Authors: Zanaruddin, S.N., Yee, P.S., Hor, S.Y., Kong, Y.H., Ghani, W.M., Mustafa, W.M., Zain, R.B., Prime, S.S., Rahman, Z.A., Cheong, S.C.
• 格式: Article
• 语言: English
• 出版: Public Library of Science 2013
• 主题: R Medicine
• 在线阅读: http://eprints.um.edu.my/8579/1/pone.0080229.pdf; http://eprints.um.edu.my/8579/; http://www.ncbi.nlm.nih.gov/pubmed/24224046

OBJECTIVES: The frequency of common oncogenic mutations and TP53 was determined in Asian oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: The OncoCarta(™) panel v1.0 assay was used to characterize oncogenic mutations. In addition, exons 4-11 of the TP53 gene were sequenced. Statistical...