Direct binding of gangliosides to Helicobacter pylori vacuolating cytotoxin (VacA) neutralizes its toxin activity

• Main Authors: Wada, Akihiro, Hasegawa, Makoto, Wong, Pooi Fong, Shirai, Emi, Shirai, Nobuaki, Tan, Li Jing, Llanes, Rafael, Hojo, Hironobu, Yamasaki, Eiki, Ichinose, Akitoyo, Ichinose, Yoshio, Senba, Masachika
• Format: Article
• Language: English
• Published: Oxford University Press 2010
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/8536/1/Direct_binding_of_gangliosides_to_Helicobacter_pylori_vacuolating_cytotoxin.pdf; http://eprints.um.edu.my/8536/; https://doi.org/10.1093/glycob/cwq014

Gangliosides are target receptors for bacterial entry, yet those present in human milk exhibit a protective role against bacterial infection. Here, we show that treatment with ganglioside mixture at a concentration of 100 mu g/mL resulted in significant inhibition of the vacuole formation activity o...