Expression of TRPV1 channels after nerve injury provides an essential delivery tool for neuropathic pain attenuation.

• Main Authors: Zakir, H.M., Mostafeezur, R.M., Suzuki, A., Hitomi, S., Suzuki, I., Maeda, T., Seo, K., Yamada, Y., Yamamura, K., Lev, S., Binshtok, A.M., Iwata, K., Kitagawa, J.
• Format: Article
• Language: English
• Published: Public Library of Science 2012
• Subjects: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry; RK Dentistry
• Online Access: http://eprints.um.edu.my/8509/2/Expression_of_TRPV1_Channels_after_Nerve_Injury.pdf; http://eprints.um.edu.my/8509/

Increased expression of the transient receptor potential vanilloid 1 (TRPV1) channels, following nerve injury, may facilitate the entry of QX-314 into nociceptive neurons in order to achieve effective and selective pain relief. In this study we hypothesized that the level of QX-314/capsaicin (QX-CAP...