Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-κB Inhibition

• Main Authors: Arbab, I.A., Looi, Chung Yeng, Abdul, A.B., Cheah, F.K., Wong, Won Fen, Sukari, M.A., Abdullah, R., Mohan, S., Syam, S., Arya, Aditya, Mustafa, Mohd Rais
• Format: Article
• Language: English
• Published: Hindawi 2012
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/8254/1/856029.pdf; http://eprints.um.edu.my/8254/; http://www.hindawi.com/journals/ecam/2012/856029/; http://dx.doi.org/10.1155/2012/856029

This study was set to investigate antiproliferative potential of dentatin (a natural coumarin isolated from Clausena excavata Burm. F) against prostate cancer and to delineate the underlying mechanism of action. Treatment with dentatin dose-dependently inhibited cell growth of PC-3 and LNCaP prostat...