Carboxymethylation of kappa-carrageenan for intestinal-targeted delivery of bioactive macromolecules

• Main Authors: Leong, K.H., Chung, L.Y., Noordin, M.I., Mohamad, K., Nishikawa, M., Onuki, Y., Morishita, M., Takayama, K.
• Format: Article
• Published: 2011
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/8156/; http://www.sciencedirect.com/science/article/pii/S0144861710007952

The work presented herein discusses the carboxymethylation of kappa-carrageenan, a natural linear polysaccharide, to afford a pH-dependent swelling property allowing for intestinal-targeted delivery of bioactive macromolecules. The carboxymethylation conditions with respect to the volume and concent...