Bioactivity-guided fractionation of the lipoxygenase and cyclooxygenase inhibiting constituents from Chisocheton polyandrus Merr

• Main Authors: Chan, K.Y., Mohamad, K., Ooi, A.J.A., Imiyabir, Z., Chung, L.Y.
• Format: Article
• Language: English
• Published: 2012
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/8153/1/Chan-2012-Bioactivity-guided_f.pdf; http://eprints.um.edu.my/8153/; http://www.sciencedirect.com/science/article/pii/S0367326X12001256

Lipoxygenase (LOX)-inhibiting compounds from the leaves of Chisocheton polyandrus Merr. were isolated in this study using a bioactivity-guided fractionation technique. Two dammarane triterpenoids, dammara-20,24-dien-3-one (1) (IC50 = 0.69 +/- 0.07 mu M) and 24-hydroxydammara-20,25-dien-3-one (2) (IC...