The subtle co-catalytic intervention of benzophenone in radical cation mediated cyclization - an improved synthesis of 2-(3 ',4 '-Dimethoxyphenyl) indoline

• Main Authors: Ariffin, Azhar, Hadi, A.H.A., Thomas, N.F., Kee, C.H., Awang, Khalijah, Weber, J.F.F., Lim, C.G., Mukhtar, M.R.
• Format: Article
• Published: 2008
• Subjects: QD Chemistry
• Online Access: http://eprints.um.edu.my/8070/; http://www.heterocycles.jp/newlibrary/libraries/abst/02546

The addition of benzophenone to a FeCl(3)/CH(2)Cl(2) mixture in the presence of 3',4'-dimethoxy-2-acetamidostilbene 17 unexpectedly leads to a dramatic improvement in yield of the indoline 20 from 38% (previously reported by us) to 75.4%, after careful examination of a variety of reaction...