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Metallo-β-lactamase–producing imipenem-resistant Pseudomonas aeruginosa clinical isolates in a university teaching hospital in Malaysia: detection of IMP-7 and first identification of IMP-4, VIM-2, and VIM-11

Ninety (n = 90) imipenem-resistant Pseudomonas aeruginosa (IRPA) clinical isolates collected randomly during 2005 to 2008 from University Malaya Medical Center were assessed for the presence of different variants of metallo-β-lactamase (MBL) genes. Polymerase chain reaction (PCR) assay detected 32 (...

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Main Authors: Khosravi, Yalda, Tay, Sun Tee, Vadivelu, Jamuna
Format: Article
Published: Elsevier 2010
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/773/
https://doi.org/10.1016/j.diagmicrobio.2010.02.010
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spelling my.um.eprints.7732019-11-11T03:49:56Z http://eprints.um.edu.my/773/ Metallo-β-lactamase–producing imipenem-resistant Pseudomonas aeruginosa clinical isolates in a university teaching hospital in Malaysia: detection of IMP-7 and first identification of IMP-4, VIM-2, and VIM-11 Khosravi, Yalda Tay, Sun Tee Vadivelu, Jamuna R Medicine Ninety (n = 90) imipenem-resistant Pseudomonas aeruginosa (IRPA) clinical isolates collected randomly during 2005 to 2008 from University Malaya Medical Center were assessed for the presence of different variants of metallo-β-lactamase (MBL) genes. Polymerase chain reaction (PCR) assay detected 32 (n = 32) MBL gene PCR-positive isolates with the presence of blaIMP gene in 14 (n = 14) and blaVIM in 18 (n = 18) isolates. Four allelic variants, blaIMP-7 (12 isolates), blaIMP-4 (2 isolates), blaVIM-2 (17 isolates), and blaVIM-11 (1 isolate), of MBL genes were identified. This study is the first report of detection of blaIMP-4, blaVIM-2, and blaVIM-11 MBL genes from IRPA clinical isolates in Malaysia. Elsevier 2010 Article PeerReviewed Khosravi, Yalda and Tay, Sun Tee and Vadivelu, Jamuna (2010) Metallo-β-lactamase–producing imipenem-resistant Pseudomonas aeruginosa clinical isolates in a university teaching hospital in Malaysia: detection of IMP-7 and first identification of IMP-4, VIM-2, and VIM-11. Diagnostic Microbiology and Infectious Disease, 67 (3). pp. 294-296. ISSN 0732-8893 https://doi.org/10.1016/j.diagmicrobio.2010.02.010 doi:10.1016/j.diagmicrobio.2010.02.010
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Khosravi, Yalda
Tay, Sun Tee
Vadivelu, Jamuna
Metallo-β-lactamase–producing imipenem-resistant Pseudomonas aeruginosa clinical isolates in a university teaching hospital in Malaysia: detection of IMP-7 and first identification of IMP-4, VIM-2, and VIM-11
description Ninety (n = 90) imipenem-resistant Pseudomonas aeruginosa (IRPA) clinical isolates collected randomly during 2005 to 2008 from University Malaya Medical Center were assessed for the presence of different variants of metallo-β-lactamase (MBL) genes. Polymerase chain reaction (PCR) assay detected 32 (n = 32) MBL gene PCR-positive isolates with the presence of blaIMP gene in 14 (n = 14) and blaVIM in 18 (n = 18) isolates. Four allelic variants, blaIMP-7 (12 isolates), blaIMP-4 (2 isolates), blaVIM-2 (17 isolates), and blaVIM-11 (1 isolate), of MBL genes were identified. This study is the first report of detection of blaIMP-4, blaVIM-2, and blaVIM-11 MBL genes from IRPA clinical isolates in Malaysia.
format Article
author Khosravi, Yalda
Tay, Sun Tee
Vadivelu, Jamuna
author_facet Khosravi, Yalda
Tay, Sun Tee
Vadivelu, Jamuna
author_sort Khosravi, Yalda
title Metallo-β-lactamase–producing imipenem-resistant Pseudomonas aeruginosa clinical isolates in a university teaching hospital in Malaysia: detection of IMP-7 and first identification of IMP-4, VIM-2, and VIM-11
title_short Metallo-β-lactamase–producing imipenem-resistant Pseudomonas aeruginosa clinical isolates in a university teaching hospital in Malaysia: detection of IMP-7 and first identification of IMP-4, VIM-2, and VIM-11
title_full Metallo-β-lactamase–producing imipenem-resistant Pseudomonas aeruginosa clinical isolates in a university teaching hospital in Malaysia: detection of IMP-7 and first identification of IMP-4, VIM-2, and VIM-11
title_fullStr Metallo-β-lactamase–producing imipenem-resistant Pseudomonas aeruginosa clinical isolates in a university teaching hospital in Malaysia: detection of IMP-7 and first identification of IMP-4, VIM-2, and VIM-11
title_full_unstemmed Metallo-β-lactamase–producing imipenem-resistant Pseudomonas aeruginosa clinical isolates in a university teaching hospital in Malaysia: detection of IMP-7 and first identification of IMP-4, VIM-2, and VIM-11
title_sort metallo-β-lactamase–producing imipenem-resistant pseudomonas aeruginosa clinical isolates in a university teaching hospital in malaysia: detection of imp-7 and first identification of imp-4, vim-2, and vim-11
publisher Elsevier
publishDate 2010
url http://eprints.um.edu.my/773/
https://doi.org/10.1016/j.diagmicrobio.2010.02.010
_version_ 1651867313584996352
score 13.209306

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