In vitro vasodilator mechanisms of the indole alkaloids rhynchophylline and isorhynchophylline, isolated from the hook of Uncaria rhynchophylla (Miquel)

• Main Authors: Zhang, W.B., Chen, C.X., Sim, S.M., Kwan, C.Y.
• Format: Article
• Language: English
• Published: 2004
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/7688/1/Zhang-2004-In_vitro_vasodilator.pdf; http://eprints.um.edu.my/7688/; http://link.springer.com/content/pdf/10.1007%2Fs00210-003-0854-9.pdf

Rhynchophylline (Rhy) and isorhynchophylline (Isorhy), indole alkaloids from Uncaria hooks, reportedly exert hypotensive and vasodilatory effects, but the mechanism of action is unclear. We therefore investigated the relaxant effects of these two isomeric alkaloids in rat arteries in vitro, in parti...