Nephrotoxicity of hump-nosed pit viper (Hypnale hypnale) venom in mice is preventable by the paraspecific Hemato polyvalent antivenom (HPA)

• Main Authors: Tan, C.H., Tan, N.H., Sim, S.M., Fung, S.Y., Jayalakshmi, P., Gnanathasan, C.A.
• Format: Article
• Published: 2012
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/7672/; http://www.sciencedirect.com/science/article/pii/S0041010112007258

Mice experimentally envenomed with Hypnale hypnale venom (1 x and 1.5x LD50) developed acute kidney injury (AKI) principally characterized by raised blood urea and creatinine. Prolonged blood clotting time and hemorrhage in lungs implied bleeding tendency. Pallor noted in most renal cortices was sug...