Assessment of pubertal development in juvenile male rats after sub-acute exposure to bisphenol A and nonylphenol

• Main Authors: Tan, B.L.L., Kassim, N.M., Mohd, M.A.
• Format: Article
• Language: English
• Published: 2003
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/7629/1/Tan-2003-Assessment_of_pubert1.pdf; http://eprints.um.edu.my/7629/; http://www.sciencedirect.com/science/article/pii/S0378427403001723

The effects of bisphenol A and nonylphenol on pubertal development in the intact juvenile/peripubertal male Sprague-Dawley rats was observed in this study from PND23-52/53. Two groups of rats were administered orally with either 100 mg/kg body weight of nonylphenol or bisphenol A. Another group of rats were administered orally with a mixture of 100 mg/kg body weight of nonylphenol and bisphenol A. Control group was administered with the vehicle of Tween-80 with corn oil (1:9 v/v). Observations made in this study included growth, age at preputial separation, thyroid, liver, testis and kidney weight and histology, epididymal and seminal vesicle plus coagulation gland weight. Nonylphenol and bisphenol A have been observed to cause delay in puberty onset as well as testicular damage in the treatment groups when compared to the control; spermatogenesis was affected in most treated rats. Bisphenol A also caused the enlargement of the kidney and hydronephrosis. Administration of nonylphenol and bisphenol A as a mixture has caused less than additive effects. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.