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Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011

From 1989 to 2011 in Kuala Lumpur, Malaysia, multiple genotypes from both respiratory syncytial virus (RSV) subgroups were found co-circulating each year. RSV-A subgroup predominated in 12 out of 17 years with the remaining years predominated by RSV-B subgroup. Local RSV strains exhibited temporal c...

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Main Authors: Khor, C.S., Sam, I.C., Hooi, P.S., Chan, Yoke Fun
Format: Article
Published: Elsevier 2013
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/7270/
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spelling my.um.eprints.72702019-05-07T08:14:50Z http://eprints.um.edu.my/7270/ Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011 Khor, C.S. Sam, I.C. Hooi, P.S. Chan, Yoke Fun R Medicine From 1989 to 2011 in Kuala Lumpur, Malaysia, multiple genotypes from both respiratory syncytial virus (RSV) subgroups were found co-circulating each year. RSV-A subgroup predominated in 12 out of 17 years with the remaining years predominated by RSV-B subgroup. Local RSV strains exhibited temporal clustering with RSV strains reported in previous epidemiological studies. Every few years, the existing predominant genotype was replaced by a new genotype. The RSV-A genotypes GA2, GA5 and GA7 were replaced by NA1 and NA2, while BA became the predominant RSV-B genotype. A unique local cluster, BA12, was seen in 2009, and the recently-described ON1 genotype with 72-nt duplication emerged in 2011. Our findings will have important implications for future vaccine intervention. Elsevier 2013 Article PeerReviewed Khor, C.S. and Sam, I.C. and Hooi, P.S. and Chan, Yoke Fun (2013) Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011. Infection, Genetics and Evolution, 14. pp. 357-360. ISSN 1567-1348
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Khor, C.S.
Sam, I.C.
Hooi, P.S.
Chan, Yoke Fun
Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011
description From 1989 to 2011 in Kuala Lumpur, Malaysia, multiple genotypes from both respiratory syncytial virus (RSV) subgroups were found co-circulating each year. RSV-A subgroup predominated in 12 out of 17 years with the remaining years predominated by RSV-B subgroup. Local RSV strains exhibited temporal clustering with RSV strains reported in previous epidemiological studies. Every few years, the existing predominant genotype was replaced by a new genotype. The RSV-A genotypes GA2, GA5 and GA7 were replaced by NA1 and NA2, while BA became the predominant RSV-B genotype. A unique local cluster, BA12, was seen in 2009, and the recently-described ON1 genotype with 72-nt duplication emerged in 2011. Our findings will have important implications for future vaccine intervention.
format Article
author Khor, C.S.
Sam, I.C.
Hooi, P.S.
Chan, Yoke Fun
author_facet Khor, C.S.
Sam, I.C.
Hooi, P.S.
Chan, Yoke Fun
author_sort Khor, C.S.
title Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011
title_short Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011
title_full Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011
title_fullStr Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011
title_full_unstemmed Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011
title_sort displacement of predominant respiratory syncytial virus genotypes in malaysia between 1989-2011
publisher Elsevier
publishDate 2013
url http://eprints.um.edu.my/7270/
_version_ 1643688006639419392
score 13.160551

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