Desensitisation of somatostatin, TRH and GHRH responses to glucose in the diabetic (Goto-Kakizaki) rat hypothalamus

We have studied the effects of glucose on the release of somatostatin (SS), TRH and GHRH from incubated hypothalami of normal and genetically diabetic, Goto-Kakizaki (GK) rats. The active isomer D-glucose caused a dose-related inhibition of SS, TRH and GHRH from normal rat hypothalami over a 20-min...

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Bibliographic Details
Main Authors: Lewis, B.M., Ismail, I.S., Issa, B., Peters, J.R., Scanlon, M.F.
Format: Article
Published: 1996
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Online Access:http://eprints.um.edu.my/7235/
http://joe.endocrinology-journals.org/content/151/1/13
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