Heterogeneity of the CYP2D6 gene among Malays in Malaysia

• Main Authors: Teh, L.K., Ismail, R., Yusoff, R., Hussein, A., Isa, M.N., Rahman, A.R.A.
• Format: Article
• Published: Journal of Clinical Pharmacy and Therapeutics 2001
• Subjects: TA Engineering (General). Civil engineering (General)
• Online Access: http://eprints.um.edu.my/5763/; http://onlinelibrary.wiley.com/store/10.1046/j.1365-2710.2001.00347.x/asset/j.1365-2710.2001.00347.x.pdf?v=1&t=hbg6eyv4&s=7171e1864e329f0f8b40f337c4cd983cd2310df8

Background: Although Malays shared an origin with Chinese, their evolution saw substantial divergences. Phenotyping studies suggested that they differed in CYP2D6 polymorphism, with higher PM prevalence but lesser right-shift for debrisoquine MRs. Objective: To study the genotype distribution of CYP...