Acceleration of wound healing potential of Benzyl N'-(Indol-3-Ylinethylidene)-Hydrazinecarbodithioate derivatives in experimental rats

The effects of topical application of Benzyl N'-(indol-3-Ylmethylidene)-Hydrazinecarbodithioate derivatives (BHC) on the process of wound healing enclosure and histology of healed wound were assessed. Five groups of adult male Sprague Dawley rats, all animals were experimentally wound in the po...

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Main Authors: Mughrabi, F.F., Ali, Hapipah Mohd, Khaledi, H., Ameen, M., Hashim, H.
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Published: 2010
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Online Access:http://eprints.um.edu.my/5315/
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spelling my.um.eprints.53152019-01-29T09:08:08Z http://eprints.um.edu.my/5315/ Acceleration of wound healing potential of Benzyl N'-(Indol-3-Ylinethylidene)-Hydrazinecarbodithioate derivatives in experimental rats Mughrabi, F.F. Ali, Hapipah Mohd Khaledi, H. Ameen, M. Hashim, H. QD Chemistry The effects of topical application of Benzyl N'-(indol-3-Ylmethylidene)-Hydrazinecarbodithioate derivatives (BHC) on the process of wound healing enclosure and histology of healed wound were assessed. Five groups of adult male Sprague Dawley rats, all animals were experimentally wound in the posterior neck area About 0.2 rnL of 10% Tween 20 solution was applied to the wound of Group 1 animals (negative control). Intrasitegel was applied topically to wounds of Group 2 animals as reference. About 0.2 mL of 25, 50 and 100 mg mL -1 of compound derivative were applied to the wounds of Group 3, 4 and 5, respectively. Macroscopically, wound dressed with compound derivative significantly healed earlier than those treated with 10% Tween 20 solution. Also wound dressed with 100 mg mL -1 compound derivative accelerate the rate of wound healing compared to those dressed with Intrasite and 25 and 50 mg mL -1 compound derivative. Histological analysis of healed wounds dresses with compound derivative showed comparatively less scar width at wound enclosure and healed wound contained less macrophages and large amount of collagen with angiogenesis compared to wounds dressed with 10% Tween 20 solution. In conclusion, wounds dressed with 100 mg mL -1 of compound derivative significantly enhanced the acceleration of the rate of wound healing enclosure and histologically healed wounds contain comparatively less macrophages and more collagen with angiogenesis. © Medwell Journals, 2010. 2010 Article PeerReviewed Mughrabi, F.F. and Ali, Hapipah Mohd and Khaledi, H. and Ameen, M. and Hashim, H. (2010) Acceleration of wound healing potential of Benzyl N'-(Indol-3-Ylinethylidene)-Hydrazinecarbodithioate derivatives in experimental rats. Research Journal of Applied Sciences, 5 (2). pp. 131-136. ISSN 1815-932X http://www.scopus.com/inward/record.url?eid=2-s2.0-77957012657&partnerID=40&md5=63c7d2e515204f806f531ed5c3b830ec 10.3923/rjasci.2010.131.136
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
spellingShingle QD Chemistry
Mughrabi, F.F.
Ali, Hapipah Mohd
Khaledi, H.
Ameen, M.
Hashim, H.
Acceleration of wound healing potential of Benzyl N'-(Indol-3-Ylinethylidene)-Hydrazinecarbodithioate derivatives in experimental rats
description The effects of topical application of Benzyl N'-(indol-3-Ylmethylidene)-Hydrazinecarbodithioate derivatives (BHC) on the process of wound healing enclosure and histology of healed wound were assessed. Five groups of adult male Sprague Dawley rats, all animals were experimentally wound in the posterior neck area About 0.2 rnL of 10% Tween 20 solution was applied to the wound of Group 1 animals (negative control). Intrasitegel was applied topically to wounds of Group 2 animals as reference. About 0.2 mL of 25, 50 and 100 mg mL -1 of compound derivative were applied to the wounds of Group 3, 4 and 5, respectively. Macroscopically, wound dressed with compound derivative significantly healed earlier than those treated with 10% Tween 20 solution. Also wound dressed with 100 mg mL -1 compound derivative accelerate the rate of wound healing compared to those dressed with Intrasite and 25 and 50 mg mL -1 compound derivative. Histological analysis of healed wounds dresses with compound derivative showed comparatively less scar width at wound enclosure and healed wound contained less macrophages and large amount of collagen with angiogenesis compared to wounds dressed with 10% Tween 20 solution. In conclusion, wounds dressed with 100 mg mL -1 of compound derivative significantly enhanced the acceleration of the rate of wound healing enclosure and histologically healed wounds contain comparatively less macrophages and more collagen with angiogenesis. © Medwell Journals, 2010.
format Article
author Mughrabi, F.F.
Ali, Hapipah Mohd
Khaledi, H.
Ameen, M.
Hashim, H.
author_facet Mughrabi, F.F.
Ali, Hapipah Mohd
Khaledi, H.
Ameen, M.
Hashim, H.
author_sort Mughrabi, F.F.
title Acceleration of wound healing potential of Benzyl N'-(Indol-3-Ylinethylidene)-Hydrazinecarbodithioate derivatives in experimental rats
title_short Acceleration of wound healing potential of Benzyl N'-(Indol-3-Ylinethylidene)-Hydrazinecarbodithioate derivatives in experimental rats
title_full Acceleration of wound healing potential of Benzyl N'-(Indol-3-Ylinethylidene)-Hydrazinecarbodithioate derivatives in experimental rats
title_fullStr Acceleration of wound healing potential of Benzyl N'-(Indol-3-Ylinethylidene)-Hydrazinecarbodithioate derivatives in experimental rats
title_full_unstemmed Acceleration of wound healing potential of Benzyl N'-(Indol-3-Ylinethylidene)-Hydrazinecarbodithioate derivatives in experimental rats
title_sort acceleration of wound healing potential of benzyl n'-(indol-3-ylinethylidene)-hydrazinecarbodithioate derivatives in experimental rats
publishDate 2010
url http://eprints.um.edu.my/5315/
http://www.scopus.com/inward/record.url?eid=2-s2.0-77957012657&partnerID=40&md5=63c7d2e515204f806f531ed5c3b830ec
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