Antioxidant, cytotoxic activities, and structure-activity relationship of gallic acid-based indole derivatives

• Main Authors: Khaledi, H., Alhadi, A.A., Yehye, W.A., Ali, Hapipah Mohd, Abdulla, Mahmood Ameen, Hassandarvish, P.
• Format: Article
• Published: Wiley-VCH Verlag 2011
• Subjects: QD Chemistry
• Online Access: http://eprints.um.edu.my/5224/; http://onlinelibrary.wiley.com/doi/10.1002/ardp.201000223/abstract; http://dx.doi.org/10.1002/ardp.201000223

A new series of gallic hydrazones containing an indole moiety was synthesized through the reaction of gallic hydrazide and different indole carboxaldehydes. Their antioxidant activities were determined on DPPH radical scavenging and inhibition of lipid peroxidation. The in-vitro cytotoxic activities...