Gastroprotective Activity and Mechanism of Novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate Complex on Ethanol-induced Gastric Ulceration
Zinc complexes were reported to have anti-ulcer activity and used as drug for the treatment of gastrointestinal disorders. A novel compound dichlorido-zinc(II)-4-(2-(5-methoxybenzylidene amino)ethyl)piperazin-1-iumphenolate (ZnHMS) was synthesized, characterized and evaluated for its gastroprotectiv...
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my.um.eprints.51342019-01-30T01:17:02Z http://eprints.um.edu.my/5134/ Gastroprotective Activity and Mechanism of Novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate Complex on Ethanol-induced Gastric Ulceration Salga, M.S. Abdelwahab, S.I. Abdulla, M.A. Ali, Hapipah Mohd QD Chemistry Zinc complexes were reported to have anti-ulcer activity and used as drug for the treatment of gastrointestinal disorders. A novel compound dichlorido-zinc(II)-4-(2-(5-methoxybenzylidene amino)ethyl)piperazin-1-iumphenolate (ZnHMS) was synthesized, characterized and evaluated for its gastroprotective activity against ethanol-induced ulcer in rats. Gross and microscopic lesions, histochemical staining of glycogen storage, biochemical and immunological parameters were taken into consideration. Oral administration of ZnHMS (30 and 60 mg/kg; 14 days) dose-dependently inhibited gastric lesions. It significantly increased the mucus content and total acidity compared to the control group (P < 0.01). Serum levels of aspartate (AST), alanine (ALT) transaminases, pro-inflammatory interleukin-6 (IL-6), tumor necrosis factor-alpha (INF-alpha) and anti-inflammatory interleukin-10 (IL-10) in the rats exposed to ethanol induced ulceration have been altered. ZnHMS considerably enhances (P < 0.05) the protection of gastric epithelia by modulating the acute alterations of AST, ALT, IL-6, IL-10, INF-alpha and stomach glycogen. Interestingly. ZnHMS did interfere with the natural release of nitric oxide. In addition, acute toxicity study revealed no abnormal sign to the rats treated with ZnHMS (2000 mg/kg). These findings suggest that the gastroprotective activity of ZnHMS might contribute in adjusting the inflammatory cytokine-mediated oxidative damage to the gastric mucosa. (C) 2011 Elsevier Ireland Ltd. All rights reserved. 2012 Article PeerReviewed Salga, M.S. and Abdelwahab, S.I. and Abdulla, M.A. and Ali, Hapipah Mohd (2012) Gastroprotective Activity and Mechanism of Novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate Complex on Ethanol-induced Gastric Ulceration. Chemico-Biological Interactions, 195 (2). pp. 144-153. ISSN 0009-2797 http://www.sciencedirect.com/science/article/pii/S0009279711003292 10.1016/j.cbi.2011.11.008 |
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QD Chemistry Salga, M.S. Abdelwahab, S.I. Abdulla, M.A. Ali, Hapipah Mohd Gastroprotective Activity and Mechanism of Novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate Complex on Ethanol-induced Gastric Ulceration |
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Zinc complexes were reported to have anti-ulcer activity and used as drug for the treatment of gastrointestinal disorders. A novel compound dichlorido-zinc(II)-4-(2-(5-methoxybenzylidene amino)ethyl)piperazin-1-iumphenolate (ZnHMS) was synthesized, characterized and evaluated for its gastroprotective activity against ethanol-induced ulcer in rats. Gross and microscopic lesions, histochemical staining of glycogen storage, biochemical and immunological parameters were taken into consideration. Oral administration of ZnHMS (30 and 60 mg/kg; 14 days) dose-dependently inhibited gastric lesions. It significantly increased the mucus content and total acidity compared to the control group (P < 0.01). Serum levels of aspartate (AST), alanine (ALT) transaminases, pro-inflammatory interleukin-6 (IL-6), tumor necrosis factor-alpha (INF-alpha) and anti-inflammatory interleukin-10 (IL-10) in the rats exposed to ethanol induced ulceration have been altered. ZnHMS considerably enhances (P < 0.05) the protection of gastric epithelia by modulating the acute alterations of AST, ALT, IL-6, IL-10, INF-alpha and stomach glycogen. Interestingly. ZnHMS did interfere with the natural release of nitric oxide. In addition, acute toxicity study revealed no abnormal sign to the rats treated with ZnHMS (2000 mg/kg). These findings suggest that the gastroprotective activity of ZnHMS might contribute in adjusting the inflammatory cytokine-mediated oxidative damage to the gastric mucosa. (C) 2011 Elsevier Ireland Ltd. All rights reserved. |
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Article |
author |
Salga, M.S. Abdelwahab, S.I. Abdulla, M.A. Ali, Hapipah Mohd |
author_facet |
Salga, M.S. Abdelwahab, S.I. Abdulla, M.A. Ali, Hapipah Mohd |
author_sort |
Salga, M.S. |
title |
Gastroprotective Activity and Mechanism of Novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate Complex on Ethanol-induced Gastric Ulceration |
title_short |
Gastroprotective Activity and Mechanism of Novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate Complex on Ethanol-induced Gastric Ulceration |
title_full |
Gastroprotective Activity and Mechanism of Novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate Complex on Ethanol-induced Gastric Ulceration |
title_fullStr |
Gastroprotective Activity and Mechanism of Novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate Complex on Ethanol-induced Gastric Ulceration |
title_full_unstemmed |
Gastroprotective Activity and Mechanism of Novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate Complex on Ethanol-induced Gastric Ulceration |
title_sort |
gastroprotective activity and mechanism of novel dichlorido-zinc(ii)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate complex on ethanol-induced gastric ulceration |
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2012 |
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http://eprints.um.edu.my/5134/ http://www.sciencedirect.com/science/article/pii/S0009279711003292 |
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1643687493917212672 |
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13.211869 |