Gastroprotective Activity and Mechanism of Novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate Complex on Ethanol-induced Gastric Ulceration

Zinc complexes were reported to have anti-ulcer activity and used as drug for the treatment of gastrointestinal disorders. A novel compound dichlorido-zinc(II)-4-(2-(5-methoxybenzylidene amino)ethyl)piperazin-1-iumphenolate (ZnHMS) was synthesized, characterized and evaluated for its gastroprotectiv...

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Main Authors: Salga, M.S., Abdelwahab, S.I., Abdulla, M.A., Ali, Hapipah Mohd
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Published: 2012
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Online Access:http://eprints.um.edu.my/5134/
http://www.sciencedirect.com/science/article/pii/S0009279711003292
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spelling my.um.eprints.51342019-01-30T01:17:02Z http://eprints.um.edu.my/5134/ Gastroprotective Activity and Mechanism of Novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate Complex on Ethanol-induced Gastric Ulceration Salga, M.S. Abdelwahab, S.I. Abdulla, M.A. Ali, Hapipah Mohd QD Chemistry Zinc complexes were reported to have anti-ulcer activity and used as drug for the treatment of gastrointestinal disorders. A novel compound dichlorido-zinc(II)-4-(2-(5-methoxybenzylidene amino)ethyl)piperazin-1-iumphenolate (ZnHMS) was synthesized, characterized and evaluated for its gastroprotective activity against ethanol-induced ulcer in rats. Gross and microscopic lesions, histochemical staining of glycogen storage, biochemical and immunological parameters were taken into consideration. Oral administration of ZnHMS (30 and 60 mg/kg; 14 days) dose-dependently inhibited gastric lesions. It significantly increased the mucus content and total acidity compared to the control group (P < 0.01). Serum levels of aspartate (AST), alanine (ALT) transaminases, pro-inflammatory interleukin-6 (IL-6), tumor necrosis factor-alpha (INF-alpha) and anti-inflammatory interleukin-10 (IL-10) in the rats exposed to ethanol induced ulceration have been altered. ZnHMS considerably enhances (P < 0.05) the protection of gastric epithelia by modulating the acute alterations of AST, ALT, IL-6, IL-10, INF-alpha and stomach glycogen. Interestingly. ZnHMS did interfere with the natural release of nitric oxide. In addition, acute toxicity study revealed no abnormal sign to the rats treated with ZnHMS (2000 mg/kg). These findings suggest that the gastroprotective activity of ZnHMS might contribute in adjusting the inflammatory cytokine-mediated oxidative damage to the gastric mucosa. (C) 2011 Elsevier Ireland Ltd. All rights reserved. 2012 Article PeerReviewed Salga, M.S. and Abdelwahab, S.I. and Abdulla, M.A. and Ali, Hapipah Mohd (2012) Gastroprotective Activity and Mechanism of Novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate Complex on Ethanol-induced Gastric Ulceration. Chemico-Biological Interactions, 195 (2). pp. 144-153. ISSN 0009-2797 http://www.sciencedirect.com/science/article/pii/S0009279711003292 10.1016/j.cbi.2011.11.008
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
spellingShingle QD Chemistry
Salga, M.S.
Abdelwahab, S.I.
Abdulla, M.A.
Ali, Hapipah Mohd
Gastroprotective Activity and Mechanism of Novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate Complex on Ethanol-induced Gastric Ulceration
description Zinc complexes were reported to have anti-ulcer activity and used as drug for the treatment of gastrointestinal disorders. A novel compound dichlorido-zinc(II)-4-(2-(5-methoxybenzylidene amino)ethyl)piperazin-1-iumphenolate (ZnHMS) was synthesized, characterized and evaluated for its gastroprotective activity against ethanol-induced ulcer in rats. Gross and microscopic lesions, histochemical staining of glycogen storage, biochemical and immunological parameters were taken into consideration. Oral administration of ZnHMS (30 and 60 mg/kg; 14 days) dose-dependently inhibited gastric lesions. It significantly increased the mucus content and total acidity compared to the control group (P < 0.01). Serum levels of aspartate (AST), alanine (ALT) transaminases, pro-inflammatory interleukin-6 (IL-6), tumor necrosis factor-alpha (INF-alpha) and anti-inflammatory interleukin-10 (IL-10) in the rats exposed to ethanol induced ulceration have been altered. ZnHMS considerably enhances (P < 0.05) the protection of gastric epithelia by modulating the acute alterations of AST, ALT, IL-6, IL-10, INF-alpha and stomach glycogen. Interestingly. ZnHMS did interfere with the natural release of nitric oxide. In addition, acute toxicity study revealed no abnormal sign to the rats treated with ZnHMS (2000 mg/kg). These findings suggest that the gastroprotective activity of ZnHMS might contribute in adjusting the inflammatory cytokine-mediated oxidative damage to the gastric mucosa. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
format Article
author Salga, M.S.
Abdelwahab, S.I.
Abdulla, M.A.
Ali, Hapipah Mohd
author_facet Salga, M.S.
Abdelwahab, S.I.
Abdulla, M.A.
Ali, Hapipah Mohd
author_sort Salga, M.S.
title Gastroprotective Activity and Mechanism of Novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate Complex on Ethanol-induced Gastric Ulceration
title_short Gastroprotective Activity and Mechanism of Novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate Complex on Ethanol-induced Gastric Ulceration
title_full Gastroprotective Activity and Mechanism of Novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate Complex on Ethanol-induced Gastric Ulceration
title_fullStr Gastroprotective Activity and Mechanism of Novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate Complex on Ethanol-induced Gastric Ulceration
title_full_unstemmed Gastroprotective Activity and Mechanism of Novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate Complex on Ethanol-induced Gastric Ulceration
title_sort gastroprotective activity and mechanism of novel dichlorido-zinc(ii)-4-(2-(5-methoxybenzylideneamino)ethyl) piperazin-1-iu mphenolate complex on ethanol-induced gastric ulceration
publishDate 2012
url http://eprints.um.edu.my/5134/
http://www.sciencedirect.com/science/article/pii/S0009279711003292
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