The influence of CYP3A gene polymorphisms on cyclosporine dose requirement in renal allograft recipients
Cyclosporine is a substrate of cytochrome P-450 3A (CYP3A) subfamily of enzymes and characterized by a narrow therapeutic range with wide interindividual variation in pharmacokinetics. A few single-nucleotide polymorphisms detected in CYP3A genes have been shown to correlate significantly with the C...
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Main Authors: | Eng, H.S., Mohamed, Z., Calne, R., Lang, C.C., Mohd, M.A., Seet, W.T., Tan, S.Y. |
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Format: | Article |
Published: |
2006
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Online Access: | http://eprints.um.edu.my/5101/ |
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