Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor-derived endothelial cells and tumor angiogenesis in vivo

• Main Authors: Chung, I., Hang, G.Z., Seshadri, M., Gillard, B.M., Yu, W.D., Foster, B.A., Trump, D.L., Johnson, C.S.
• Format: Article
• Published: 2009
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/5089/

Calcitriol (1,25-dihydroxycholecalciferol), the major active form of vitamin D, is antiproliferative in tumor cells and tumor-derived endothelial cells (TDEC). These actions of calcitriol are mediated at least in part by vitamin D receptor (VDR), which is expressed in many tissues including endothel...