Epigenetic silencing of CYP24 in tumor-derived endothelial cells contributes to selective growth inhibition by calcitriol

• Main Authors: Chung, I., Karpf, A.R., Muindi, J.R., Conroy, J.M., Nowak, N.J., Johnson, C.S., Trump, D.L.
• Format: Article
• Language: English
• Published: 2007
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/5079/1/Chung-2007-Epigenetic_silencing.pdf; http://eprints.um.edu.my/5079/

Calcitriol (1,25-dihydroxycholecalciferol), the most active form of vitamin D, has selective anti-proliferative effects on tumor-derived endothelial cells (TDEC) compared with Matrigel-derived endothelial cells (MDEC). Although both cell types have an intact vitamin D receptor-signaling axis, this s...