Salivary biomarkers: Effective diagnostic tool for oral leukoplakia and oral squamous cell carcinoma

ObjectiveTo identify potential salivary biomarkers for the diagnosis and monitoring of disease progression in oral squamous cell carcinoma and oral leukoplakia.Materials and MethodsAn advance search from PubMed and Hindawi was performed with keywords; oral leukoplakia/oral squamous cell carcinoma, s...

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Main Authors: Liew, Yoon Xuan, Kadir, Kathreena, Phan, Chia Wei, Leong, Kok Hoong, Kallarakkal, Thomas George, Tilakaratne, Wanninayake Mudiyanselage
Format: Article
Published: Wiley 2024
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Online Access:http://eprints.um.edu.my/47139/
https://doi.org/10.1111/odi.14835
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spelling my.um.eprints.471392024-12-09T06:45:39Z http://eprints.um.edu.my/47139/ Salivary biomarkers: Effective diagnostic tool for oral leukoplakia and oral squamous cell carcinoma Liew, Yoon Xuan Kadir, Kathreena Phan, Chia Wei Leong, Kok Hoong Kallarakkal, Thomas George Tilakaratne, Wanninayake Mudiyanselage RK Dentistry ObjectiveTo identify potential salivary biomarkers for the diagnosis and monitoring of disease progression in oral squamous cell carcinoma and oral leukoplakia.Materials and MethodsAn advance search from PubMed and Hindawi was performed with keywords; oral leukoplakia/oral squamous cell carcinoma, salivary biomarker and diagnosis/prognosis. An additional search of articles was done through a manual search from the Google Scholar database.ResultsTwenty studies involving salivary biomarkers as diagnostic tools for oral squamous cell carcinoma and/or oral leukoplakia were identified. A narrative review was carried out.ConclusionSingle or multiple salivary biomarkers reported by most studies have shown great potential as diagnostic tools for oral squamous cell carcinoma and oral leukoplakia. However, the validation of sensitivity and specificity should be carried out to ensure the accuracy of the biomarkers. Furthermore, a standardised method for saliva collection should be established to prevent variability in the expression of biomarkers. Wiley 2024-09 Article PeerReviewed Liew, Yoon Xuan and Kadir, Kathreena and Phan, Chia Wei and Leong, Kok Hoong and Kallarakkal, Thomas George and Tilakaratne, Wanninayake Mudiyanselage (2024) Salivary biomarkers: Effective diagnostic tool for oral leukoplakia and oral squamous cell carcinoma. Oral Diseases, 30 (6). pp. 3591-3599. ISSN 1354-523X, DOI https://doi.org/10.1111/odi.14835 <https://doi.org/10.1111/odi.14835>. https://doi.org/10.1111/odi.14835 10.1111/odi.14835
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic RK Dentistry
spellingShingle RK Dentistry
Liew, Yoon Xuan
Kadir, Kathreena
Phan, Chia Wei
Leong, Kok Hoong
Kallarakkal, Thomas George
Tilakaratne, Wanninayake Mudiyanselage
Salivary biomarkers: Effective diagnostic tool for oral leukoplakia and oral squamous cell carcinoma
description ObjectiveTo identify potential salivary biomarkers for the diagnosis and monitoring of disease progression in oral squamous cell carcinoma and oral leukoplakia.Materials and MethodsAn advance search from PubMed and Hindawi was performed with keywords; oral leukoplakia/oral squamous cell carcinoma, salivary biomarker and diagnosis/prognosis. An additional search of articles was done through a manual search from the Google Scholar database.ResultsTwenty studies involving salivary biomarkers as diagnostic tools for oral squamous cell carcinoma and/or oral leukoplakia were identified. A narrative review was carried out.ConclusionSingle or multiple salivary biomarkers reported by most studies have shown great potential as diagnostic tools for oral squamous cell carcinoma and oral leukoplakia. However, the validation of sensitivity and specificity should be carried out to ensure the accuracy of the biomarkers. Furthermore, a standardised method for saliva collection should be established to prevent variability in the expression of biomarkers.
format Article
author Liew, Yoon Xuan
Kadir, Kathreena
Phan, Chia Wei
Leong, Kok Hoong
Kallarakkal, Thomas George
Tilakaratne, Wanninayake Mudiyanselage
author_facet Liew, Yoon Xuan
Kadir, Kathreena
Phan, Chia Wei
Leong, Kok Hoong
Kallarakkal, Thomas George
Tilakaratne, Wanninayake Mudiyanselage
author_sort Liew, Yoon Xuan
title Salivary biomarkers: Effective diagnostic tool for oral leukoplakia and oral squamous cell carcinoma
title_short Salivary biomarkers: Effective diagnostic tool for oral leukoplakia and oral squamous cell carcinoma
title_full Salivary biomarkers: Effective diagnostic tool for oral leukoplakia and oral squamous cell carcinoma
title_fullStr Salivary biomarkers: Effective diagnostic tool for oral leukoplakia and oral squamous cell carcinoma
title_full_unstemmed Salivary biomarkers: Effective diagnostic tool for oral leukoplakia and oral squamous cell carcinoma
title_sort salivary biomarkers: effective diagnostic tool for oral leukoplakia and oral squamous cell carcinoma
publisher Wiley
publishDate 2024
url http://eprints.um.edu.my/47139/
https://doi.org/10.1111/odi.14835
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score 13.222552