Hemisynthesis of Pentacyclic Triterpenoids from Diospyros foxworthyi with In vitro and In silico Anti-malarial Evaluation

• Main Authors: Ghani, Muhammad Solehin Abd, Abu Bakar, Nur Ain Latifhaa, Ramadani, Arba Pramundita, Nugraha, Arde Toga, Awang, Khalijah, Omar, Mohammad Tasyriq Che, Supratman, Unang, Kamarulzaman, Ezatul Ezleen, Taib, Mohamad Nurul Azmi Mohamad
• Format: Article
• Published: Bentham Science Publishers 2024
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://eprints.um.edu.my/47083/; https://doi.org/10.2174/0113852728294047240315063815

A total of twelve pentacyclic triterpenoid derivatives based on betulin (1) and lupeol (2) scaffolds isolated from Diospyros foxworthyi were hemisynthesized by acylation or acetylation reactions with appropriate acid chloride or acetic anhydride. The structures of the hemisynthesised compounds were...