Shedding light on the molecular interaction between the Hepatitis B virus inhibitor, clevudine, and human serum albumin: Thermodynamic, spectroscopic, microscopic, and in silico analyses

• Main Authors: Abubakar, Mujaheed, Kandandapani, Salanee, Mohamed, Saharuddin, Abd Halim, Adyani Azizah, Tayyab, Saad
• Format: Article
• Published: ELSEVIER 2022
• Subjects: QR Microbiology
• Online Access: http://eprints.um.edu.my/46170/; https://doi.org/10.1016/j.molliq.2022.120737

The molecular interaction between clevudine (CLV), a hepatitis B virus inhibitor, and human serum albu-min (HSA), the major transporter in plasma, was investigated via fluorescence, UV-vis absorption, circu-lar dichroism (CD), atomic force microscopy (AFM), and molecular modelling approaches. A stea...