Risk and prognostic significance of tuberculosis in patients from the treat Asia HIV Observational Database

• Main Authors: Zhou, J.L., Elliott, J., Li, P.C.K., Lim, P.L., Kiertiburanakul, S., Kumarasamy, N., Merati, T.P., Pujari, S., Chen, Y.M.A., Phanuphak, P., Vonthanak, S., Sirisanthana, T., Sungkanuparph, S., Lee, C.K.C., Kamarulzaman, Adeeba, Oka, S., Zhang, F., Tau, G., Ditangco, R.
• Format: Article
• Published: BMC 2009
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/4614/

To assess the risk and the prognostic significance of tuberculosis (TB) diagnosis in patients from The TREAT Asia HIV Observational Database, a multi-centre prospective cohort of HIV-infected patients receiving HIV care in the Asia-Pacific region. Methods: The risk of TB diagnosis after recruitment was assessed in patients with prospective follow-up. TB diagnosis was fitted as a time-dependent variable in assessing overall survival. Results: At baseline, 22 of patients were diagnosed with TB. TB incidence was 1.98 per 100 person-years during follow up, with predictors including younger age, lower recent CD4 count, duration of antiretroviral treatment, and living in high TB burden countries. Among 3279 patients during 6968 person-years, 142 died (2.04 per 100 person-years). Compared to patients with CDC category A or B illness only, mortality was marginally higher in patients with single Non-TB AIDS defining illness (ADI), or TB only (adjusted HR 1.35, p = 0.173) and highest in patients with multiple non-TB AIDS or both TB and other ADI (adjusted HR 2.21, p < 0.001). Conclusion: The risk of TB diagnosis was associated with increasing immunodeficiency and partly reduced by antiretroviral treatment. The prognosis of developing TB appeared to be similar to that following a diagnosis of other non-TB ADI.