Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoli-ne-based molecular hybrids in targeted therapeutics and beyond

• Main Authors: Ravindar, Lekkala, Hasbullah, Siti Aishah, Rakesh, K. P., Raheem, Saki, Agustar, Hani Kartini, Ismail, Norzila, Ling, Lau Yee, Hassan, Nurul Izzaty
• Format: Article
• Published: Elsevier 2024
• Subjects: R Medicine (General); RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/45939/; https://doi.org/10.1016/j.ejmech.2023.116043

Amongst heterocyclic compounds, quinoline and its derivatives are advantaged scaffolds that appear as a significant assembly motif for developing new drug entities. Aminoquinoline moiety has gained significant attention among researchers in the 21stcentury. Considering the biological and pharmaceutical importance of aminoquinoline derivatives, herein, we review the recent developments (since 2019) in various biological activities of the 4-aminoquinoline scaffold hybridized with diverse heterocyclic moieties such as quinoline, pyridine, pyrimidine, triazine, dioxine, piperazine, pyrazoline, piperidine, imidazole, indole, oxadiazole, carbazole, dioxole, thiazole, benzothiazole, pyrazole, phthalimide, adamantane, benzochromene, and pyridinone. Moreover, by gaining knowledge about SARs, structural insights, and molecular targets, this review may help medicinal chemists design cost-effective, selective, safe, and more potent 4-aminoquinoline hybrids for diverse biological activities.