Association of the Reduced Function Met420del Polymorphism of SLC22A1 with Metformin-Induced Gastrointestinal Intolerance in Ethiopian Patients with Type 2 Diabetes Mellitus

• Main Authors: Degaga, Abraham, Sirgu, Sisay, Huri, Hasniza Zaman, Sim, Maw Shin, Loganadan, Navin Kumar, Kebede, Tedla, Tegene, Birhanemeskel, Engidawork, Ephrem, Shibeshi, Workineh
• Format: Article
• Published: Dove Medical Press 2024
• Subjects: RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/45847/; https://doi.org/10.2147/PGPM.S457374

Background: Despite its widespread use and favored profile, there are extensive variations in the treatment outcome of metformin therapy. Furthermore, studies reported that the inter-individual variability in the occurrence of metformin treatment associated side effects were related to the differenc...