Flavonoid diversity and roles in the lipopolysaccharide-mediated inflammatory response of monocytes and macrophages
Targeting lipopolysaccharide (LPS)/toll-like receptor 4 signaling in mononuclear phagocytes has been explored for the treatment of inflammation and inflammation-related disorders. However, only a few key targets have been translated into clinical applications. Flavonoids, a class of ubiquitous plant...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Published: |
Newlands Press Ltd
2024
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/45796/ https://doi.org/10.4155/fmc-2023-0174 |
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| Summary: | Targeting lipopolysaccharide (LPS)/toll-like receptor 4 signaling in mononuclear phagocytes has been explored for the treatment of inflammation and inflammation-related disorders. However, only a few key targets have been translated into clinical applications. Flavonoids, a class of ubiquitous plant secondary metabolites, possess a privileged scaffold which serves as a valuable template for designing pharmacologically active compounds directed against diseases with inflammatory components. This perspective provides a general overview of the diversity of flavonoids and their multifaceted mechanisms that interfere with LPS-induced signaling in monocytes and macrophages. Focus is placed on flavonoids targetingMD-2, I kappa B kinases, c-Jun N-terminal kinases, extracellular signal-regulated kinase, p38 MAPK and PI3K/Akt or modulating LPS-related gene expression. GRAPHICS] . |
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