Implementing HLA-B*58:01 testing prior to allopurinol initiation in Malaysian primary care setting: A qualitative study from doctors' and patients' perspective

• Main Authors: Ng, Wei Leik, Hussein, Norita, Ng, Chirk Jenn, Qureshi, Nadeem, Lee, Yew Kong, Kwan, Zhenli, Kee, Boon Pin, Then, Sue-Mian, Abdul Malik, Tun Firzara, Mohd Zaidan, Fatimah Zahrah, Azmi, Siti Umi Fairuz, Lang, Chim C.
• Format: Article
• Published: Public Library of Science 2024
• Subjects: R Medicine (General)
• Online Access: http://eprints.um.edu.my/45795/; https://doi.org/10.1371/journal.pone.0296498

IntroductionAllopurinol, the first-line treatment for chronic gout, is a common causative drug for severe cutaneous adverse reactions (SCAR). HLA-B*58:01 allele was strongly associated with allopurinol-induced SCAR in Asian countries such as Taiwan, Japan, Thailand and Malaysia. HLA-B*58:01 screenin...