Age-specific breast and ovarian cancer risks associated with germline BRCA1 or BRCA2 pathogenic variants - an Asian study of 572 families

• Main Authors: Ho, Weang-Kee, Hassan, Nur Tiara, Yoon, Sook-Yee, Yang, Xin, Lim, Joanna M. C., Ishak, Nur Diana Binte, Ho, Peh Joo, Wijaya, Eldarina A., Ng, Patsy Pei-Sze, Luccarini, Craig, Allen, Jamie, Tai, Mei-Chee, Chiang, Jianbang, Zhang, Zewen, See, Mee-Hoong, Thong, Meow-Keong, Woo, Yin-Ling, Dunning, Alison M., Hartman, Mikael, Yip, Cheng-Har, Taib, Nur Aishah Mohd, Easton, Douglas F., Li, Jingme, Ngeow, Joanne, Antoniou, Antonis C., Teo, Soo-Hwang
• Format: Article
• Published: Elsevier 2024
• Subjects: R Medicine (General)
• Online Access: http://eprints.um.edu.my/45660/; https://doi.org/10.1016/j.lanwpc.2024.101017

Background Clinical management of Asian BRCA1 and BRCA2 pathogenic variants (PV) carriers remains challenging due to imprecise age-specific breast (BC) and ovarian cancer (OC) risks estimates. We aimed to refine these estimates using six multi-ethnic studies in Asia. Methods Data were collected on 2...