Non-lamellar lyotropic liquid crystalline nanoparticles as nanocarriers for enhanced drug encapsulation of atorvastatin calcium and proanthocyanidins

• Main Authors: Maslizan, Mardhiah, Haris, Muhammad Salahuddin, Ajat, Mokrish, Jamil, Siti Nurul Ain Md, Azhar, Shah Christirani, Zahid, N. Idayu, Azmi, Intan Diana Mat
• Format: Article
• Published: Elsevier 2024
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://eprints.um.edu.my/45607/; https://doi.org/10.1016/j.chemphyslip.2024.105377

Atorvastatin calcium (ATV) and proanthocyanidins (PAC) have a strong antioxidant activity, that can benefit to reduce the atherosclerotic plaque progression. Unfortunately, the bioavailability of ATV is greatly reduced due to its limited drug solubility while the PAC drug is unstable upon exposure t...