Antimicrobial and Antiproliferative Effects of Zingiberaceae Oils: A Natural Solution for Oral Health

• Main Authors: Amil, Muhammad Amirul, Rahman, Syarifah Nur Syed Abdul, Yap, Lee Fah, Razak, Fathilah Abdul, Bakri, Marina Mohd, Salem, Lamis S. O., Lim, Xiu Yi, Reduan, Nur Athirah, Sim, Kae Shin
• Format: Article
• Published: Wiley 2024
• Subjects: QH Natural history; RK Dentistry
• Online Access: http://eprints.um.edu.my/45587/; https://doi.org/10.1002/cbdv.202301836

Essential oils have been recognised for their potential benefits in oral care. The aim of this study was to evaluate the antibacterial and antiproliferative activity of essential oils derived from four Zingiberaceae species. A combination of GC/MS and GC-FID was employed to analyse these essential oils. The results showed that beta-myrcene (79.77 %) followed by ethyl-cinnamate (40.14 %), beta-curcumene (34.90 %), and alloaromadendrene (25.15 %) as the primary constituents of Curcuma mangga, Curcuma xanthorrhiza, Kaempferia galanga and Curcuma aeruginosa, respectively. The Zingiberaceae oils were tested for their antibacterial activity against oral bacteria using the disc diffusion test. Curcuma xanthorrhiza oil showed the largest inhibition zones against Streptococcus mitis (19.50 +/- 2.22 mm) and Streptococcus sanguinis (15.04 +/- 3.05 mm). Similarly, Curcuma mangga oil exhibited significant antibacterial activity against Streptococcus mutans (12.55 +/- 0.45 mm) and mixed oral bacteria (15.03 +/- 3.82 mm). Furthermore, the MTT viability assay revealed moderate inhibitory activity of these essential oils against H103 and ORL-204 oral cancer cells. The study findings demonstrate that Curcuma xanthorrhiza and Curcuma mangga essential oils have potent antibacterial properties, suggesting their potential use as natural alternatives to synthetic antibacterial agents in oral care products. However, further investigations are necessary to fully explore their therapeutic applications. image