Pharmacological inhibition of endoplasmic reticulum stress mitigates osteoporosis in a mouse model of hindlimb suspension

• Main Authors: Al-Daghestani, Hiba, Qaisar, Rizwan, Al Kawas, Sausan, Ghani, Nurhafizah, Rani, K. G. Aghila, Azeem, Muhammad, Hasnan, Hijaz Kamal, Kassim, Nur Karyatee, Samsudin, A. R.
• Format: Article
• Published: Nature Research 2024
• Subjects: Q Science (General)
• Online Access: http://eprints.um.edu.my/45552/; https://doi.org/10.1038/s41598-024-54944-7

Hindlimb suspension (HLS) mice exhibit osteoporosis of the hindlimb bones and may be an excellent model to test pharmacological interventions. We investigated the effects of inhibiting endoplasmic reticulum (ER) stress with 4-phenyl butyrate (4-PBA) on the morphology, physicochemical properties, and...