Formation of Inclusion Complex of Curcumin and Tetrahydrocurcumin Prevents Angiogenesis by Inhibiting VEGF Activity: An in-silico Study

• Main Authors: Dewi, Firli Rahmah Primula, Tambunan, Ulie Vianissa Dwiutami, Bari, Putri Amatul, Farid, Muhammad Ardiansyah, Anjani, Nadira Aisha, Wahyuningsih, Sri Puji Astuti, Saik, Amy Yi Hsan, Keong, Yong Yoke, Lim, Vuanghao, Tan, Wen Nee, Alshawsh, Mohammed Abdullah Mahdi
• Format: Article
• Published: Penerbit Universiti Kebangsaan Malaysia 2024
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/45499/; https://doi.org/10.17576/jsm-2024-5303-13

Curcumin and tetrahydrocurcumin (THC) are known for their anticancer properties, but limited solubility in water hinders their effectiveness against cancer. In this study, we conducted an in silico exploration of 0-cyclodextrin's potential to form inclusion complexes with curcumin or THC. The a...