Effects of the prenatal and postnatal nurturing environment on the phenotype and gut microbiota of mice with polycystic ovary syndrome induced by prenatal androgen exposure: a cross-fostering study

• Main Authors: Kusamoto, Akari, Harada, Miyuki, Minemura, Ayaka, Matsumoto, Asami, Oka, Kentaro, Takahashi, Motomichi, Sakaguchi, Nanoka, Azhary, Jerilee M.K., Koike, Hiroshi, Xu, Zixin, Tanaka, Tsurugi, Urata, Yoko, Kunitomi, Chisato, Takahashi, Nozomi, Wada-Hiraike, Osamu, Hirota, Yasushi, Osuga, Yutaka
• Format: Article
• Published: Frontiers Media 2024
• Subjects: R Medicine (General)
• Online Access: http://eprints.um.edu.my/45408/; https://doi.org/10.3389/fcell.2024.1365624

The gut microbiome is implicated in the pathogenesis of polycystic ovary syndrome (PCOS), and prenatal androgen exposure is involved in the development of PCOS in later life. Our previous study of a mouse model of PCOS induced by prenatal dihydrotestosterone (DHT) exposure showed that the reproducti...