A review of recent advances of cellulose-based intelligent-responsive hydrogels as vehicles for controllable drug delivery system

To realize the maximum therapeutic activity of medicine and protect the body from the adverse effects of active ingredients, drug delivery systems (DDS) featured with targeted transportation sites and controllable release have captured extensive attention over the past decades. Hydrogels with unique...

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Main Authors: Gong, Jingwei, Hou, Leilei, Ching, Yern Chee, Ching, Kuan Yong, Hai, Nguyen Dai, Chuah, Cheng Hock
Format: Article
Published: Elsevier 2024
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Online Access:http://eprints.um.edu.my/45358/
https://doi.org/10.1016/j.ijbiomac.2024.130525
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spelling my.um.eprints.453582024-10-14T09:00:44Z http://eprints.um.edu.my/45358/ A review of recent advances of cellulose-based intelligent-responsive hydrogels as vehicles for controllable drug delivery system Gong, Jingwei Hou, Leilei Ching, Yern Chee Ching, Kuan Yong Hai, Nguyen Dai Chuah, Cheng Hock QD Chemistry TP Chemical technology To realize the maximum therapeutic activity of medicine and protect the body from the adverse effects of active ingredients, drug delivery systems (DDS) featured with targeted transportation sites and controllable release have captured extensive attention over the past decades. Hydrogels with unique three-dimensional (3D) porous structures present tunable capacity, controllable degradation, various stimuli sensitivity, therapeutic agents encapsulation, and loaded drugs protection properties, which endow hydrogels with bred-in-the-bone advantages as vehicles for drug delivery. In recent years, with the impressive consciousness of the ``back-to-nature'' concept, biomass materials are becoming the `rising star' as the hydrogels building blocks for controlled drug release carriers due to their biodegradability, biocompatibility, and non-toxicity properties. In particular, cellulose and its derivatives are promising candidates for fabricating hydrogels as their rich sources and high availability, and various smart cellulose-based hydrogels as targeted carriers under exogenous such as light, electric field, and magnetic field or endogenous such as pH, temperature, ionic strength, and redox gradients. In this review, we summarized the main synthetic strategies of smart cellulose-based hydrogels including physical and chemical cross-linking, and illustrated the detailed intelligent-responsive mechanism of hydrogels in DDS under external stimulus. Additionally, the ongoing development and challenges of cellulose-based hydrogels in the biomedical field are also presented. Elsevier 2024-04 Article PeerReviewed Gong, Jingwei and Hou, Leilei and Ching, Yern Chee and Ching, Kuan Yong and Hai, Nguyen Dai and Chuah, Cheng Hock (2024) A review of recent advances of cellulose-based intelligent-responsive hydrogels as vehicles for controllable drug delivery system. International Journal of Biological Macromolecules, 264 (2). p. 130525. ISSN 0141-8130, DOI https://doi.org/10.1016/j.ijbiomac.2024.130525 <https://doi.org/10.1016/j.ijbiomac.2024.130525>. https://doi.org/10.1016/j.ijbiomac.2024.130525 10.1016/j.ijbiomac.2024.130525
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
TP Chemical technology
spellingShingle QD Chemistry
TP Chemical technology
Gong, Jingwei
Hou, Leilei
Ching, Yern Chee
Ching, Kuan Yong
Hai, Nguyen Dai
Chuah, Cheng Hock
A review of recent advances of cellulose-based intelligent-responsive hydrogels as vehicles for controllable drug delivery system
description To realize the maximum therapeutic activity of medicine and protect the body from the adverse effects of active ingredients, drug delivery systems (DDS) featured with targeted transportation sites and controllable release have captured extensive attention over the past decades. Hydrogels with unique three-dimensional (3D) porous structures present tunable capacity, controllable degradation, various stimuli sensitivity, therapeutic agents encapsulation, and loaded drugs protection properties, which endow hydrogels with bred-in-the-bone advantages as vehicles for drug delivery. In recent years, with the impressive consciousness of the ``back-to-nature'' concept, biomass materials are becoming the `rising star' as the hydrogels building blocks for controlled drug release carriers due to their biodegradability, biocompatibility, and non-toxicity properties. In particular, cellulose and its derivatives are promising candidates for fabricating hydrogels as their rich sources and high availability, and various smart cellulose-based hydrogels as targeted carriers under exogenous such as light, electric field, and magnetic field or endogenous such as pH, temperature, ionic strength, and redox gradients. In this review, we summarized the main synthetic strategies of smart cellulose-based hydrogels including physical and chemical cross-linking, and illustrated the detailed intelligent-responsive mechanism of hydrogels in DDS under external stimulus. Additionally, the ongoing development and challenges of cellulose-based hydrogels in the biomedical field are also presented.
format Article
author Gong, Jingwei
Hou, Leilei
Ching, Yern Chee
Ching, Kuan Yong
Hai, Nguyen Dai
Chuah, Cheng Hock
author_facet Gong, Jingwei
Hou, Leilei
Ching, Yern Chee
Ching, Kuan Yong
Hai, Nguyen Dai
Chuah, Cheng Hock
author_sort Gong, Jingwei
title A review of recent advances of cellulose-based intelligent-responsive hydrogels as vehicles for controllable drug delivery system
title_short A review of recent advances of cellulose-based intelligent-responsive hydrogels as vehicles for controllable drug delivery system
title_full A review of recent advances of cellulose-based intelligent-responsive hydrogels as vehicles for controllable drug delivery system
title_fullStr A review of recent advances of cellulose-based intelligent-responsive hydrogels as vehicles for controllable drug delivery system
title_full_unstemmed A review of recent advances of cellulose-based intelligent-responsive hydrogels as vehicles for controllable drug delivery system
title_sort review of recent advances of cellulose-based intelligent-responsive hydrogels as vehicles for controllable drug delivery system
publisher Elsevier
publishDate 2024
url http://eprints.um.edu.my/45358/
https://doi.org/10.1016/j.ijbiomac.2024.130525
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