Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays

The common variants in the fat mass- and obesity-associated (FTO) gene have been previously found to be associated with obesity in various adult populations. The objective of the present study was to investigate whether the single nucleotide polymorphisms (SNPs) and linkage disequilibrium (LD) block...

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Main Authors: Apalasamy, Y.D., Ming, M.F., Rampal, S., Bulgiba, A., Mohamed, Z.
Format: Article
Language:English
Published: 2012
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Online Access:http://eprints.um.edu.my/4510/1/Genetic_association_of_SNPs_in_the_FTO_gene_and.pdf
http://eprints.um.edu.my/4510/
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spelling my.um.eprints.45102013-01-16T00:50:06Z http://eprints.um.edu.my/4510/ Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays Apalasamy, Y.D. Ming, M.F. Rampal, S. Bulgiba, A. Mohamed, Z. R Medicine The common variants in the fat mass- and obesity-associated (FTO) gene have been previously found to be associated with obesity in various adult populations. The objective of the present study was to investigate whether the single nucleotide polymorphisms (SNPs) and linkage disequilibrium (LD) blocks in various regions of the FTO gene are associated with predisposition to obesity in Malaysian Malays. Thirty-one FTO SNPs were genotyped in 587 (158 obese and 429 non-obese) Malaysian Malay subjects. Obesity traits and lipid profiles were measured and single-marker association testing, LD testing, and haplotype association analysis were performed. LD analysis of the FTO SNPs revealed the presence of 57 regions with complete LD (D� = 1.0). In addition, we detected the association of rs17817288 with low-density lipoprotein cholesterol. The FTO gene may therefore be involved in lipid metabolism in Malaysian Malays. Two haplotype blocks were present in this region of the FTO gene, but no particular haplotype was found to be significantly associated with an increased risk of obesity in Malaysian Malays 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/4510/1/Genetic_association_of_SNPs_in_the_FTO_gene_and.pdf Apalasamy, Y.D. and Ming, M.F. and Rampal, S. and Bulgiba, A. and Mohamed, Z. (2012) Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays. Brazilian Journal of Medical and Biological Research (REVIEW). 0-0. ISSN 0100-879X 10.1590/S0100-879X2012007500134
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine
spellingShingle R Medicine
Apalasamy, Y.D.
Ming, M.F.
Rampal, S.
Bulgiba, A.
Mohamed, Z.
Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays
description The common variants in the fat mass- and obesity-associated (FTO) gene have been previously found to be associated with obesity in various adult populations. The objective of the present study was to investigate whether the single nucleotide polymorphisms (SNPs) and linkage disequilibrium (LD) blocks in various regions of the FTO gene are associated with predisposition to obesity in Malaysian Malays. Thirty-one FTO SNPs were genotyped in 587 (158 obese and 429 non-obese) Malaysian Malay subjects. Obesity traits and lipid profiles were measured and single-marker association testing, LD testing, and haplotype association analysis were performed. LD analysis of the FTO SNPs revealed the presence of 57 regions with complete LD (D� = 1.0). In addition, we detected the association of rs17817288 with low-density lipoprotein cholesterol. The FTO gene may therefore be involved in lipid metabolism in Malaysian Malays. Two haplotype blocks were present in this region of the FTO gene, but no particular haplotype was found to be significantly associated with an increased risk of obesity in Malaysian Malays
format Article
author Apalasamy, Y.D.
Ming, M.F.
Rampal, S.
Bulgiba, A.
Mohamed, Z.
author_facet Apalasamy, Y.D.
Ming, M.F.
Rampal, S.
Bulgiba, A.
Mohamed, Z.
author_sort Apalasamy, Y.D.
title Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays
title_short Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays
title_full Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays
title_fullStr Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays
title_full_unstemmed Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays
title_sort genetic association of snps in the fto gene and predisposition to obesity in malaysian malays
publishDate 2012
url http://eprints.um.edu.my/4510/1/Genetic_association_of_SNPs_in_the_FTO_gene_and.pdf
http://eprints.um.edu.my/4510/
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