Interaction mechanism of a cysteine protease inhibitor, odanacatib, with human serum albumin: In vitro and bioinformatics studies

• Main Authors: Asngari, Nurul Jannah Mohd, Bakar, Khairul Azreena, Feroz, Shevin Rizal, Razak, Fathilah Abdul, Abd Halim, Adyani Azizah
• Format: Article
• Published: ELSEVIER 2024
• Subjects: RK Dentistry
• Online Access: http://eprints.um.edu.my/44156/; https://doi.org/10.1016/j.bpc.2023.107140

Odanacatib (ODN) is a selective cathepsin K inhibitor that acts as an anti-resorptive agent to treat osteoporosis. ODN is also found effective in reducing the effect of severe periodontitis. The interaction between ODN and human serum albumin (HSA) was investigated using spectroscopic, microscopic,...