Preparation and characterization of stattic-loaded albumin nanoparticles for antimetastatic cancer treatment

• Main Authors: Kwa, Yee Chu, Anasamy, Theebaa, Foo, Yiing Yee, Leo, Bey Fen, Chung, Ivy, Kiew, Lik Voon, Chung, Lip Yong
• Format: Article
• Published: Bentham Science Publishers 2022
• Subjects: R Medicine; RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/43597/; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85134252436&doi=10.2174%2f2210303112666220330115110&partnerID=40&md5=aa743d07fa06a826b6733a53c677caee

Background: Stattic offers a unique inhibitory effect on the STAT3 signaling pathway, a crucial mechanism in the progression of metastatic cancer. However, the development of Stattic has been impeded by its hydrophobicity and lack of specificity. To overcome these limitations, encapsulation of Statt...