Fishing for synucleinopathy models
Synucleinopathies such as Parkinson’s disease (PD) are incurable neurodegenerative conditions characterised by the abnormal aggregation of α-synuclein protein in neuronal cells. In PD, fibrillary synuclein aggregation forms Lewy bodies and Lewy neu-rites in the substantia nigra and cortex on the bra...
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my.um.eprints.434632023-10-31T05:57:32Z http://eprints.um.edu.my/43463/ Fishing for synucleinopathy models Mohd Noor, Suzita Norazit, Anwar R Medicine Synucleinopathies such as Parkinson’s disease (PD) are incurable neurodegenerative conditions characterised by the abnormal aggregation of α-synuclein protein in neuronal cells. In PD, fibrillary synuclein aggregation forms Lewy bodies and Lewy neu-rites in the substantia nigra and cortex on the brain. Dementia with Lewy bodies and multiple system atrophy are also associated with α-synuclein protein abnormalities. α-synuclein is one of three synuclein proteins, and while its precise function is still unknown, one hypothesis posits that α-synuclein propagates from the enteric nervous system through the vagus nerve and into the brain, resulting in synucleinopathy. Studies on synucleinopathies should thus encompass not only the central nervous system but must necessarily include the gut and microbiome. The zebrafish (Danio rerio) is a well-established model for human neuronal pathologies and have been used in studies ranging from genetic models of hereditary disorders to neurotoxin-induced neurodegeneration as well as gut-brain-axis studies. There is significant genetic homology between zebrafish and mammalian vertebrates which is what makes the zebrafish so amenable to modelling human conditions but in the case of synucleinopa-thies, the zebrafish notably does not possess an α-synuclein homolog. Synuclein orthologs are present in the zebrafish however, and transgenic zebrafish that carry human α-synuclein have been generated. In addition, the zebrafish is a highly advantageous model and ideal replacement for reducing the use of mammalian models. This review discusses the application of the zebrafish as a model for synucleinopathies in efforts to further understand synuclein function and explore therapeutic strategies. © 2022, Korean Society of Fisheries and Aquatic Sciences. All rights reserved. Korean Society of Fisheries and Aquatic Sciences 2022 Article PeerReviewed Mohd Noor, Suzita and Norazit, Anwar (2022) Fishing for synucleinopathy models. Fisheries and Aquatic Sciences, 25 (3). 117 -139. ISSN 2234-1749, DOI https://doi.org/10.47853/FAS.2022.e11 <https://doi.org/10.47853/FAS.2022.e11>. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85128735847&doi=10.47853%2fFAS.2022.e11&partnerID=40&md5=8fa5914aaeed1e6d86fa5b607d791432 10.47853/FAS.2022.e11 |
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Synucleinopathies such as Parkinson’s disease (PD) are incurable neurodegenerative conditions characterised by the abnormal aggregation of α-synuclein protein in neuronal cells. In PD, fibrillary synuclein aggregation forms Lewy bodies and Lewy neu-rites in the substantia nigra and cortex on the brain. Dementia with Lewy bodies and multiple system atrophy are also associated with α-synuclein protein abnormalities. α-synuclein is one of three synuclein proteins, and while its precise function is still unknown, one hypothesis posits that α-synuclein propagates from the enteric nervous system through the vagus nerve and into the brain, resulting in synucleinopathy. Studies on synucleinopathies should thus encompass not only the central nervous system but must necessarily include the gut and microbiome. The zebrafish (Danio rerio) is a well-established model for human neuronal pathologies and have been used in studies ranging from genetic models of hereditary disorders to neurotoxin-induced neurodegeneration as well as gut-brain-axis studies. There is significant genetic homology between zebrafish and mammalian vertebrates which is what makes the zebrafish so amenable to modelling human conditions but in the case of synucleinopa-thies, the zebrafish notably does not possess an α-synuclein homolog. Synuclein orthologs are present in the zebrafish however, and transgenic zebrafish that carry human α-synuclein have been generated. In addition, the zebrafish is a highly advantageous model and ideal replacement for reducing the use of mammalian models. This review discusses the application of the zebrafish as a model for synucleinopathies in efforts to further understand synuclein function and explore therapeutic strategies. © 2022, Korean Society of Fisheries and Aquatic Sciences. All rights reserved. |
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Mohd Noor, Suzita Norazit, Anwar |
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Mohd Noor, Suzita Norazit, Anwar |
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Mohd Noor, Suzita |
title |
Fishing for synucleinopathy models |
title_short |
Fishing for synucleinopathy models |
title_full |
Fishing for synucleinopathy models |
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Fishing for synucleinopathy models |
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Fishing for synucleinopathy models |
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fishing for synucleinopathy models |
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Korean Society of Fisheries and Aquatic Sciences |
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2022 |
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http://eprints.um.edu.my/43463/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-85128735847&doi=10.47853%2fFAS.2022.e11&partnerID=40&md5=8fa5914aaeed1e6d86fa5b607d791432 |
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