The oral, gut microbiota and cardiometabolic health of indigenous orang asli communities

The Orang Asli (OA) of Malaysia have been relatively understudied where little is known about their oral and gut microbiomes. As human health is closely intertwined with the human microbiome, this study first assessed the cardiometabolic health in four OA communities ranging from urban, rural to sem...

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Main Authors: Yeo, Li-Fang, Lee, Soo Ching, Palanisamy, Uma Devi, Khalid, B.A.K., Ayub, Qasim, Lim, Shu Yong, Lim, Yvonne Ai Lian, Phipps, Maude Elvira
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Published: Frontiers Media S.A. 2022
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Online Access:http://eprints.um.edu.my/43415/
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spelling my.um.eprints.434152023-11-02T08:21:26Z http://eprints.um.edu.my/43415/ The oral, gut microbiota and cardiometabolic health of indigenous orang asli communities Yeo, Li-Fang Lee, Soo Ching Palanisamy, Uma Devi Khalid, B.A.K. Ayub, Qasim Lim, Shu Yong Lim, Yvonne Ai Lian Phipps, Maude Elvira QR Microbiology QR180 Immunology The Orang Asli (OA) of Malaysia have been relatively understudied where little is known about their oral and gut microbiomes. As human health is closely intertwined with the human microbiome, this study first assessed the cardiometabolic health in four OA communities ranging from urban, rural to semi-nomadic hunter-gatherers. The urban Temuan suffered from poorer cardiometabolic health while rural OA communities were undergoing epidemiological transition. The oral microbiota of the OA were characterised by sequencing the V4 region of the 16S rRNA gene. The OA oral microbiota were unexpectedly homogenous, with comparably low alpha diversity across all four communities. The rural Jehai and Temiar PP oral microbiota were enriched for uncharacterised bacteria, exhibiting potential for discoveries. This finding also highlights the importance of including under-represented populations in large cohort studies. The Temuan oral microbiota were also elevated in opportunistic pathogens such as Corynebacterium, Prevotella, and Mogibacterium, suggesting possible oral dysbiosis in these urban settlers. The semi-nomadic Jehai gut microbiota had the highest alpha diversity, while urban Temuan exhibited the lowest. Rural OA gut microbiota were distinct from urban-like microbiota and were elevated in bacteria genera such as Prevotella 2, Prevotella 9, Lachnospiraceae ND3007, and Solobacterium. Urban Temuan microbiota were enriched in Odoribacter, Blautia, Parabacetroides, Bacteroides and Ruminococcacecae UCG-013. This study brings to light the current health trend of these indigenous people who have minimal access to healthcare and lays the groundwork for future, in-depth studies in these populations. Copyright © 2022 Yeo, Lee, Palanisamy, Khalid, Ayub, Lim, Lim and Phipps. Frontiers Media S.A. 2022-04-22 Article PeerReviewed Yeo, Li-Fang and Lee, Soo Ching and Palanisamy, Uma Devi and Khalid, B.A.K. and Ayub, Qasim and Lim, Shu Yong and Lim, Yvonne Ai Lian and Phipps, Maude Elvira (2022) The oral, gut microbiota and cardiometabolic health of indigenous orang asli communities. Frontiers in Cellular and Infection Microbiology, 12. ISSN 2235-2988, DOI https://doi.org/10.3389/fcimb.2022.812345 <https://doi.org/10.3389/fcimb.2022.812345>. 10.3389/fcimb.2022.812345
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QR Microbiology
QR180 Immunology
spellingShingle QR Microbiology
QR180 Immunology
Yeo, Li-Fang
Lee, Soo Ching
Palanisamy, Uma Devi
Khalid, B.A.K.
Ayub, Qasim
Lim, Shu Yong
Lim, Yvonne Ai Lian
Phipps, Maude Elvira
The oral, gut microbiota and cardiometabolic health of indigenous orang asli communities
description The Orang Asli (OA) of Malaysia have been relatively understudied where little is known about their oral and gut microbiomes. As human health is closely intertwined with the human microbiome, this study first assessed the cardiometabolic health in four OA communities ranging from urban, rural to semi-nomadic hunter-gatherers. The urban Temuan suffered from poorer cardiometabolic health while rural OA communities were undergoing epidemiological transition. The oral microbiota of the OA were characterised by sequencing the V4 region of the 16S rRNA gene. The OA oral microbiota were unexpectedly homogenous, with comparably low alpha diversity across all four communities. The rural Jehai and Temiar PP oral microbiota were enriched for uncharacterised bacteria, exhibiting potential for discoveries. This finding also highlights the importance of including under-represented populations in large cohort studies. The Temuan oral microbiota were also elevated in opportunistic pathogens such as Corynebacterium, Prevotella, and Mogibacterium, suggesting possible oral dysbiosis in these urban settlers. The semi-nomadic Jehai gut microbiota had the highest alpha diversity, while urban Temuan exhibited the lowest. Rural OA gut microbiota were distinct from urban-like microbiota and were elevated in bacteria genera such as Prevotella 2, Prevotella 9, Lachnospiraceae ND3007, and Solobacterium. Urban Temuan microbiota were enriched in Odoribacter, Blautia, Parabacetroides, Bacteroides and Ruminococcacecae UCG-013. This study brings to light the current health trend of these indigenous people who have minimal access to healthcare and lays the groundwork for future, in-depth studies in these populations. Copyright © 2022 Yeo, Lee, Palanisamy, Khalid, Ayub, Lim, Lim and Phipps.
format Article
author Yeo, Li-Fang
Lee, Soo Ching
Palanisamy, Uma Devi
Khalid, B.A.K.
Ayub, Qasim
Lim, Shu Yong
Lim, Yvonne Ai Lian
Phipps, Maude Elvira
author_facet Yeo, Li-Fang
Lee, Soo Ching
Palanisamy, Uma Devi
Khalid, B.A.K.
Ayub, Qasim
Lim, Shu Yong
Lim, Yvonne Ai Lian
Phipps, Maude Elvira
author_sort Yeo, Li-Fang
title The oral, gut microbiota and cardiometabolic health of indigenous orang asli communities
title_short The oral, gut microbiota and cardiometabolic health of indigenous orang asli communities
title_full The oral, gut microbiota and cardiometabolic health of indigenous orang asli communities
title_fullStr The oral, gut microbiota and cardiometabolic health of indigenous orang asli communities
title_full_unstemmed The oral, gut microbiota and cardiometabolic health of indigenous orang asli communities
title_sort oral, gut microbiota and cardiometabolic health of indigenous orang asli communities
publisher Frontiers Media S.A.
publishDate 2022
url http://eprints.um.edu.my/43415/
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score 13.209306